EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION

Concomitant infection is known to decrease non-specific immunity levels, thus negatively affecting clinical outcomes in tuberculosis patients. Development of specific immune response against most common pediatric infections, e.g., pneumococcal infection, is possible both in children with latent tube...

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Autores principales:	I. F. Dovgalyuk, T. S. Drozdenko, A. A. Starshinova, N. V. Korneva, S. M. Kharith
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	vaccination pneumococcal vaccine children tuberculosis infection diagnostics immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cf0ecad1f51f4010ba76abd7b896d9f0
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spelling	oai:doaj.org-article:cf0ecad1f51f4010ba76abd7b896d9f02021-11-18T08:03:46ZEFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION1563-06252313-741X10.15789/1563-0625-2017-1-73-80https://doaj.org/article/cf0ecad1f51f4010ba76abd7b896d9f02017-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1167https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XConcomitant infection is known to decrease non-specific immunity levels, thus negatively affecting clinical outcomes in tuberculosis patients. Development of specific immune response against most common pediatric infections, e.g., pneumococcal infection, is possible both in children with latent tuberculosis and in respiratory tuberculosis. The study contains data concerning results of immunization with Pneumo23 vaccine against pneumococcal infection in 35 children (3 to 14 years old) with different manifestations of MBT infection observed at the St. Petersburg Research Institute of Phthisiopulmonology. The vaccination efficiency was evaluated by incidence of acute respiratory infectionsm acute otitis media, and community pneumonias within one year before and after vaccination performed. Clinical safety of the vaccination was determined as the number of general and local reactions registered following vaccination.Incidence of post-vaccinal reactions did not differ significantly between the clinical groups and did not exceed the values reported by the vaccine manufacturer. Post-vaccinal period was event-free in 94.3% of vaccinated children, without any negative effects upon the underlying tuberculosis process. In Group 2, all the children were complication-free over the post-vaccinal period. Both groups exhibited a statistically significant increase of IGg levels by the post-vaccination day 14…45. The PPV23 vaccination was not followed by postvaccinal complications, or worsening of tuberculosis infection. Hence, anti-pneumococcal vaccination is effective for prevention of acute respiratory infections, both in MBT-infected children and in patients with local tuberculosis affection.I. F. DovgalyukT. S. DrozdenkoA. A. StarshinovaN. V. KornevaS. M. KharithSPb RAACIarticlevaccinationpneumococcal vaccinechildrentuberculosis infection diagnosticsimmunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 1, Pp 73-80 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	vaccination pneumococcal vaccine children tuberculosis infection diagnostics immunity Immunologic diseases. Allergy RC581-607
spellingShingle	vaccination pneumococcal vaccine children tuberculosis infection diagnostics immunity Immunologic diseases. Allergy RC581-607 I. F. Dovgalyuk T. S. Drozdenko A. A. Starshinova N. V. Korneva S. M. Kharith EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION
description	Concomitant infection is known to decrease non-specific immunity levels, thus negatively affecting clinical outcomes in tuberculosis patients. Development of specific immune response against most common pediatric infections, e.g., pneumococcal infection, is possible both in children with latent tuberculosis and in respiratory tuberculosis. The study contains data concerning results of immunization with Pneumo23 vaccine against pneumococcal infection in 35 children (3 to 14 years old) with different manifestations of MBT infection observed at the St. Petersburg Research Institute of Phthisiopulmonology. The vaccination efficiency was evaluated by incidence of acute respiratory infectionsm acute otitis media, and community pneumonias within one year before and after vaccination performed. Clinical safety of the vaccination was determined as the number of general and local reactions registered following vaccination.Incidence of post-vaccinal reactions did not differ significantly between the clinical groups and did not exceed the values reported by the vaccine manufacturer. Post-vaccinal period was event-free in 94.3% of vaccinated children, without any negative effects upon the underlying tuberculosis process. In Group 2, all the children were complication-free over the post-vaccinal period. Both groups exhibited a statistically significant increase of IGg levels by the post-vaccination day 14…45. The PPV23 vaccination was not followed by postvaccinal complications, or worsening of tuberculosis infection. Hence, anti-pneumococcal vaccination is effective for prevention of acute respiratory infections, both in MBT-infected children and in patients with local tuberculosis affection.
format	article
author	I. F. Dovgalyuk T. S. Drozdenko A. A. Starshinova N. V. Korneva S. M. Kharith
author_facet	I. F. Dovgalyuk T. S. Drozdenko A. A. Starshinova N. V. Korneva S. M. Kharith
author_sort	I. F. Dovgalyuk
title	EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION
title_short	EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION
title_full	EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION
title_fullStr	EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION
title_full_unstemmed	EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION
title_sort	efficiency of pneumococcal vaccine in children with different patterns of tuberculosis infection
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/cf0ecad1f51f4010ba76abd7b896d9f0
work_keys_str_mv	AT ifdovgalyuk efficiencyofpneumococcalvaccineinchildrenwithdifferentpatternsoftuberculosisinfection AT tsdrozdenko efficiencyofpneumococcalvaccineinchildrenwithdifferentpatternsoftuberculosisinfection AT aastarshinova efficiencyofpneumococcalvaccineinchildrenwithdifferentpatternsoftuberculosisinfection AT nvkorneva efficiencyofpneumococcalvaccineinchildrenwithdifferentpatternsoftuberculosisinfection AT smkharith efficiencyofpneumococcalvaccineinchildrenwithdifferentpatternsoftuberculosisinfection
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EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION

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