Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study

Abstract During the development of atherosclerotic lesion, s-RNYs (small RNAs of about 24/34 nucleotides) are derived by the processing of long Ro-associated non-coding RNAs (RNYs) in macrophages. The levels of serum s-RNYs have been found significantly upregulated in patients with coronary heart di...

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Autores principales:	Vera L. Costa, Jean-Bernard Ruidavets, Vanina Bongard, Bertrand Perret, Emanuela Repetto, Maria G. Stathopoulou, Fabrizio Serra, Mohamed Benahmed, Claire Mauduit, Valerie Grandjean, Jean Ferrières, Laurent O. Martinez, Michele Trabucchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf138d4890ba4109ae52d4f21226794f
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spelling	oai:doaj.org-article:cf138d4890ba4109ae52d4f21226794f2021-12-02T10:49:11ZPrediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study10.1038/s41598-021-81221-82045-2322https://doaj.org/article/cf138d4890ba4109ae52d4f21226794f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81221-8https://doaj.org/toc/2045-2322Abstract During the development of atherosclerotic lesion, s-RNYs (small RNAs of about 24/34 nucleotides) are derived by the processing of long Ro-associated non-coding RNAs (RNYs) in macrophages. The levels of serum s-RNYs have been found significantly upregulated in patients with coronary heart disease (CHD) compared to age-matched CHD-free individuals. The present study aimed to examine the predictive value of serum s-RNYs for CHD events in the general male population. Within the frame of nested-case–control study, the GENES study, we measured the absolute expression of a RNY-derived small RNA, the s-RNY1-5p, in the serum of individuals (without CHD at baseline) who encountered a CHD event within 12 years of follow-up (n = 30) (Cases) and compared them to individuals who remained event-free (Controls) (n = 30). The expression of s-RNY1-5p in serum was significantly upregulated in Cases compared to Controls (p = 0.027). The proportion of CHD event-free was significantly higher among individuals with serum s-RNY1-5p below the median value (631 molecules/mL). In a multivariable model adjusted for age, smoking, hypertension, diabetes and dyslipidemia, the risk of CHD events increased more than fourfold in individuals with serum s-RNY1-5p above the median value (HR, 4.36; 95% CI 1.22–15.60). A positive association with CHD events was also observed when considering s-RNY1-5p as a continuous variable (p = 0.022). Based on our results, we conclude that serum s-RNY1-5p is an independent predictor of CHD events in a general male population and might be a relevant biomarker for early detection of cardiovascular diseases.Vera L. CostaJean-Bernard RuidavetsVanina BongardBertrand PerretEmanuela RepettoMaria G. StathopoulouFabrizio SerraMohamed BenahmedClaire MauduitValerie GrandjeanJean FerrièresLaurent O. MartinezMichele TrabucchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vera L. Costa Jean-Bernard Ruidavets Vanina Bongard Bertrand Perret Emanuela Repetto Maria G. Stathopoulou Fabrizio Serra Mohamed Benahmed Claire Mauduit Valerie Grandjean Jean Ferrières Laurent O. Martinez Michele Trabucchi Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study
description	Abstract During the development of atherosclerotic lesion, s-RNYs (small RNAs of about 24/34 nucleotides) are derived by the processing of long Ro-associated non-coding RNAs (RNYs) in macrophages. The levels of serum s-RNYs have been found significantly upregulated in patients with coronary heart disease (CHD) compared to age-matched CHD-free individuals. The present study aimed to examine the predictive value of serum s-RNYs for CHD events in the general male population. Within the frame of nested-case–control study, the GENES study, we measured the absolute expression of a RNY-derived small RNA, the s-RNY1-5p, in the serum of individuals (without CHD at baseline) who encountered a CHD event within 12 years of follow-up (n = 30) (Cases) and compared them to individuals who remained event-free (Controls) (n = 30). The expression of s-RNY1-5p in serum was significantly upregulated in Cases compared to Controls (p = 0.027). The proportion of CHD event-free was significantly higher among individuals with serum s-RNY1-5p below the median value (631 molecules/mL). In a multivariable model adjusted for age, smoking, hypertension, diabetes and dyslipidemia, the risk of CHD events increased more than fourfold in individuals with serum s-RNY1-5p above the median value (HR, 4.36; 95% CI 1.22–15.60). A positive association with CHD events was also observed when considering s-RNY1-5p as a continuous variable (p = 0.022). Based on our results, we conclude that serum s-RNY1-5p is an independent predictor of CHD events in a general male population and might be a relevant biomarker for early detection of cardiovascular diseases.
format	article
author	Vera L. Costa Jean-Bernard Ruidavets Vanina Bongard Bertrand Perret Emanuela Repetto Maria G. Stathopoulou Fabrizio Serra Mohamed Benahmed Claire Mauduit Valerie Grandjean Jean Ferrières Laurent O. Martinez Michele Trabucchi
author_facet	Vera L. Costa Jean-Bernard Ruidavets Vanina Bongard Bertrand Perret Emanuela Repetto Maria G. Stathopoulou Fabrizio Serra Mohamed Benahmed Claire Mauduit Valerie Grandjean Jean Ferrières Laurent O. Martinez Michele Trabucchi
author_sort	Vera L. Costa
title	Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study
title_short	Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study
title_full	Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study
title_fullStr	Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study
title_full_unstemmed	Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study
title_sort	prediction of coronary heart disease incidence in a general male population by circulating non-coding small rna srny1-5p in a nested case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf138d4890ba4109ae52d4f21226794f
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Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study

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