Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications

Abstract Early differential diagnosis of several motor neuron diseases (MNDs) is extremely challenging due to the high number of overlapped symptoms. The routine clinical practice is based on clinical history and examination, usually accompanied by electrophysiological tests. However, although previ...

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Autores principales: Alberto Greco, Maria Rosa Chiesa, Ilaria Da Prato, Anna Maria Romanelli, Cristina Dolciotti, Gabriella Cavallini, Silvia Maria Masciandaro, Enzo Pasquale Scilingo, Renata Del Carratore, Paolo Bongioanni
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:cf1770b8409c473dac85167af072cf3c2021-12-02T12:09:25ZUsing blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications10.1038/s41598-021-82940-82045-2322https://doaj.org/article/cf1770b8409c473dac85167af072cf3c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82940-8https://doaj.org/toc/2045-2322Abstract Early differential diagnosis of several motor neuron diseases (MNDs) is extremely challenging due to the high number of overlapped symptoms. The routine clinical practice is based on clinical history and examination, usually accompanied by electrophysiological tests. However, although previous studies have demonstrated the involvement of altered metabolic pathways, biomarker-based monitoring tools are still far from being applied. In this study, we aim at characterizing and discriminating patients with involvement of both upper and lower motor neurons (i.e., amyotrophic lateral sclerosis (ALS) patients) from those with selective involvement of the lower motor neuron (LMND), by using blood data exclusively. To this end, in the last ten years, we built a database including 692 blood data and related clinical observations from 55 ALS and LMND patients. Each blood sample was described by 108 analytes. Starting from this outstanding number of features, we performed a characterization of the two groups of patients through statistical and classification analyses of blood data. Specifically, we implemented a support vector machine with recursive feature elimination (SVM-RFE) to automatically diagnose each patient into the ALS or LMND groups and to recognize whether they had a fast or slow disease progression. The classification strategy through the RFE algorithm also allowed us to reveal the most informative subset of blood analytes including novel potential biomarkers of MNDs. Our results show that we successfully devised subject-independent classifiers for the differential diagnosis and prognosis of ALS and LMND with remarkable average accuracy (up to 94%), using blood data exclusively.Alberto GrecoMaria Rosa ChiesaIlaria Da PratoAnna Maria RomanelliCristina DolciottiGabriella CavalliniSilvia Maria MasciandaroEnzo Pasquale ScilingoRenata Del CarratorePaolo BongioanniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alberto Greco
Maria Rosa Chiesa
Ilaria Da Prato
Anna Maria Romanelli
Cristina Dolciotti
Gabriella Cavallini
Silvia Maria Masciandaro
Enzo Pasquale Scilingo
Renata Del Carratore
Paolo Bongioanni
Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
description Abstract Early differential diagnosis of several motor neuron diseases (MNDs) is extremely challenging due to the high number of overlapped symptoms. The routine clinical practice is based on clinical history and examination, usually accompanied by electrophysiological tests. However, although previous studies have demonstrated the involvement of altered metabolic pathways, biomarker-based monitoring tools are still far from being applied. In this study, we aim at characterizing and discriminating patients with involvement of both upper and lower motor neurons (i.e., amyotrophic lateral sclerosis (ALS) patients) from those with selective involvement of the lower motor neuron (LMND), by using blood data exclusively. To this end, in the last ten years, we built a database including 692 blood data and related clinical observations from 55 ALS and LMND patients. Each blood sample was described by 108 analytes. Starting from this outstanding number of features, we performed a characterization of the two groups of patients through statistical and classification analyses of blood data. Specifically, we implemented a support vector machine with recursive feature elimination (SVM-RFE) to automatically diagnose each patient into the ALS or LMND groups and to recognize whether they had a fast or slow disease progression. The classification strategy through the RFE algorithm also allowed us to reveal the most informative subset of blood analytes including novel potential biomarkers of MNDs. Our results show that we successfully devised subject-independent classifiers for the differential diagnosis and prognosis of ALS and LMND with remarkable average accuracy (up to 94%), using blood data exclusively.
format article
author Alberto Greco
Maria Rosa Chiesa
Ilaria Da Prato
Anna Maria Romanelli
Cristina Dolciotti
Gabriella Cavallini
Silvia Maria Masciandaro
Enzo Pasquale Scilingo
Renata Del Carratore
Paolo Bongioanni
author_facet Alberto Greco
Maria Rosa Chiesa
Ilaria Da Prato
Anna Maria Romanelli
Cristina Dolciotti
Gabriella Cavallini
Silvia Maria Masciandaro
Enzo Pasquale Scilingo
Renata Del Carratore
Paolo Bongioanni
author_sort Alberto Greco
title Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
title_short Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
title_full Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
title_fullStr Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
title_full_unstemmed Using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
title_sort using blood data for the differential diagnosis and prognosis of motor neuron diseases: a new dataset for machine learning applications
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cf1770b8409c473dac85167af072cf3c
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