Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study

Abstract Vascular endothelial growth factor (VEGF) has been implicated in the pathophysiology of stress-related mental disorders. However, VEGF levels have seldom been compared across mental disorders and never by isoforms. Pathophysiological processes involving leakage of astrocyte-derived extracel...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Johanna Wallensten, Fariborz Mobarrez, Marie Åsberg, Kristian Borg, Aniella Beser, Alexander Wilczek, Anna Nager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf19456f6ca54fdd8e78c71884b4766b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf19456f6ca54fdd8e78c71884b4766b
record_format	dspace
spelling	oai:doaj.org-article:cf19456f6ca54fdd8e78c71884b4766b2021-12-02T16:46:34ZIsoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study10.1038/s41598-021-96313-82045-2322https://doaj.org/article/cf19456f6ca54fdd8e78c71884b4766b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96313-8https://doaj.org/toc/2045-2322Abstract Vascular endothelial growth factor (VEGF) has been implicated in the pathophysiology of stress-related mental disorders. However, VEGF levels have seldom been compared across mental disorders and never by isoforms. Pathophysiological processes involving leakage of astrocyte-derived extracellular vesicles (EVs) across the blood–brain barrier could be associated with VEGF levels in patients with stress-related mental disorders. This cross-sectional study compared plasma levels of VEGF121, VEGF165, and VEGF121 + VEGF165 (VEGFtotal) in patients with stress-induced exhaustion disorder (SED) (n = 31), patients with major depressive disorder (MDD) (n = 31), and healthy controls (n = 61). It also analyzed the correlation between VEGF and astrocyte-derived EVs in plasma. An enzyme-linked immunosorbent assay (ELISA) was used to measure VEGF121 and VEGF165 in citrate plasma, and flow cytometry was used to measure astrocyte-derived EVs in plasma. The mean concentration of soluble VEGF121 (sVEGF121) was significantly higher in patients with SED than healthy controls (P = 0.043). Mean sVEGF165 was significantly lower in patients with MDD than patients with SED (P = 0.004) or healthy controls (P = 0.037). Mean sVEGFtotal was significantly higher in patients with SED than in patients with MDD (P = 0.021) and also higher in patients with SED than healthy controls (P = 0.040). Levels of sVEGF121 were positively correlated with levels of astrocyte-derived EVs only in patients with SED (P = 0.0128). The same was true of levels of sVEGFtotal and astrocyte-derived EVs (P = 0.0046). Differing levels of VEGF isoforms may reflect different pathophysiological mechanisms in SED and MDD. Further research is needed to better understand the potential roles of VEGF isoforms and astrocyte-derived EVs in mental disorders.Johanna WallenstenFariborz MobarrezMarie ÅsbergKristian BorgAniella BeserAlexander WilczekAnna NagerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johanna Wallensten Fariborz Mobarrez Marie Åsberg Kristian Borg Aniella Beser Alexander Wilczek Anna Nager Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
description	Abstract Vascular endothelial growth factor (VEGF) has been implicated in the pathophysiology of stress-related mental disorders. However, VEGF levels have seldom been compared across mental disorders and never by isoforms. Pathophysiological processes involving leakage of astrocyte-derived extracellular vesicles (EVs) across the blood–brain barrier could be associated with VEGF levels in patients with stress-related mental disorders. This cross-sectional study compared plasma levels of VEGF121, VEGF165, and VEGF121 + VEGF165 (VEGFtotal) in patients with stress-induced exhaustion disorder (SED) (n = 31), patients with major depressive disorder (MDD) (n = 31), and healthy controls (n = 61). It also analyzed the correlation between VEGF and astrocyte-derived EVs in plasma. An enzyme-linked immunosorbent assay (ELISA) was used to measure VEGF121 and VEGF165 in citrate plasma, and flow cytometry was used to measure astrocyte-derived EVs in plasma. The mean concentration of soluble VEGF121 (sVEGF121) was significantly higher in patients with SED than healthy controls (P = 0.043). Mean sVEGF165 was significantly lower in patients with MDD than patients with SED (P = 0.004) or healthy controls (P = 0.037). Mean sVEGFtotal was significantly higher in patients with SED than in patients with MDD (P = 0.021) and also higher in patients with SED than healthy controls (P = 0.040). Levels of sVEGF121 were positively correlated with levels of astrocyte-derived EVs only in patients with SED (P = 0.0128). The same was true of levels of sVEGFtotal and astrocyte-derived EVs (P = 0.0046). Differing levels of VEGF isoforms may reflect different pathophysiological mechanisms in SED and MDD. Further research is needed to better understand the potential roles of VEGF isoforms and astrocyte-derived EVs in mental disorders.
format	article
author	Johanna Wallensten Fariborz Mobarrez Marie Åsberg Kristian Borg Aniella Beser Alexander Wilczek Anna Nager
author_facet	Johanna Wallensten Fariborz Mobarrez Marie Åsberg Kristian Borg Aniella Beser Alexander Wilczek Anna Nager
author_sort	Johanna Wallensten
title	Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
title_short	Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
title_full	Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
title_fullStr	Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
title_full_unstemmed	Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
title_sort	isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf19456f6ca54fdd8e78c71884b4766b
work_keys_str_mv	AT johannawallensten isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy AT fariborzmobarrez isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy AT marieasberg isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy AT kristianborg isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy AT aniellabeser isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy AT alexanderwilczek isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy AT annanager isoformsofsolublevascularendothelialgrowthfactorinstressrelatedmentaldisordersacrosssectionalstudy
_version_	1718383422282399744

Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study

Ejemplares similares