Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link

Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Herlinda Bonilla-Jaime, Helena Zeleke, Asheebo Rojas, Claudia Espinosa-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sleep seizures epilepsy neuroinflammation neurodegeneration Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/cf19f6229bb84310906165b4a626cf41
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf19f6229bb84310906165b4a626cf41
record_format	dspace
spelling	oai:doaj.org-article:cf19f6229bb84310906165b4a626cf412021-11-25T17:57:33ZSleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link10.3390/ijms2222125311422-00671661-6596https://doaj.org/article/cf19f6229bb84310906165b4a626cf412021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12531https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activation) may be a potential link between sleep deprivation and seizures. Here, we review the mechanisms by which sleep deprivation induces neuroinflammation and propose that neuroinflammation synergizes with seizure activity to worsen neurodegeneration in the epileptic brain. Additionally, we highlight the relevance of sleep interventions, often overlooked by physicians, to manage seizures, prevent epilepsy-related mortality, and improve quality of life.Herlinda Bonilla-JaimeHelena ZelekeAsheebo RojasClaudia Espinosa-GarciaMDPI AGarticlesleepseizuresepilepsyneuroinflammationneurodegenerationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12531, p 12531 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep seizures epilepsy neuroinflammation neurodegeneration Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sleep seizures epilepsy neuroinflammation neurodegeneration Biology (General) QH301-705.5 Chemistry QD1-999 Herlinda Bonilla-Jaime Helena Zeleke Asheebo Rojas Claudia Espinosa-Garcia Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
description	Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activation) may be a potential link between sleep deprivation and seizures. Here, we review the mechanisms by which sleep deprivation induces neuroinflammation and propose that neuroinflammation synergizes with seizure activity to worsen neurodegeneration in the epileptic brain. Additionally, we highlight the relevance of sleep interventions, often overlooked by physicians, to manage seizures, prevent epilepsy-related mortality, and improve quality of life.
format	article
author	Herlinda Bonilla-Jaime Helena Zeleke Asheebo Rojas Claudia Espinosa-Garcia
author_facet	Herlinda Bonilla-Jaime Helena Zeleke Asheebo Rojas Claudia Espinosa-Garcia
author_sort	Herlinda Bonilla-Jaime
title	Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
title_short	Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
title_full	Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
title_fullStr	Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
title_full_unstemmed	Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
title_sort	sleep disruption worsens seizures: neuroinflammation as a potential mechanistic link
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cf19f6229bb84310906165b4a626cf41
work_keys_str_mv	AT herlindabonillajaime sleepdisruptionworsensseizuresneuroinflammationasapotentialmechanisticlink AT helenazeleke sleepdisruptionworsensseizuresneuroinflammationasapotentialmechanisticlink AT asheeborojas sleepdisruptionworsensseizuresneuroinflammationasapotentialmechanisticlink AT claudiaespinosagarcia sleepdisruptionworsensseizuresneuroinflammationasapotentialmechanisticlink
_version_	1718411831889887232

Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link

Ejemplares similares