BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

Abstract Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under path...

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Autores principales:	Kazuya Morita, Naoyuki Matsumoto, Kengo Saito, Toshihide Hamabe-Horiike, Keishi Mizuguchi, Yohei Shinmyo, Hiroshi Kawasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf1dda2aa83c475798dc28df94fd5519
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spelling	oai:doaj.org-article:cf1dda2aa83c475798dc28df94fd55192021-12-02T14:58:45ZBMP signaling alters aquaporin-4 expression in the mouse cerebral cortex10.1038/s41598-021-89997-52045-2322https://doaj.org/article/cf1dda2aa83c475798dc28df94fd55192021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89997-5https://doaj.org/toc/2045-2322Abstract Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.Kazuya MoritaNaoyuki MatsumotoKengo SaitoToshihide Hamabe-HoriikeKeishi MizuguchiYohei ShinmyoHiroshi KawasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuya Morita Naoyuki Matsumoto Kengo Saito Toshihide Hamabe-Horiike Keishi Mizuguchi Yohei Shinmyo Hiroshi Kawasaki BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
description	Abstract Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.
format	article
author	Kazuya Morita Naoyuki Matsumoto Kengo Saito Toshihide Hamabe-Horiike Keishi Mizuguchi Yohei Shinmyo Hiroshi Kawasaki
author_facet	Kazuya Morita Naoyuki Matsumoto Kengo Saito Toshihide Hamabe-Horiike Keishi Mizuguchi Yohei Shinmyo Hiroshi Kawasaki
author_sort	Kazuya Morita
title	BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
title_short	BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
title_full	BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
title_fullStr	BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
title_full_unstemmed	BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
title_sort	bmp signaling alters aquaporin-4 expression in the mouse cerebral cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf1dda2aa83c475798dc28df94fd5519
work_keys_str_mv	AT kazuyamorita bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex AT naoyukimatsumoto bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex AT kengosaito bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex AT toshihidehamabehoriike bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex AT keishimizuguchi bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex AT yoheishinmyo bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex AT hiroshikawasaki bmpsignalingaltersaquaporin4expressioninthemousecerebralcortex
_version_	1718389291276566528

BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

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