Assessing encapsulation of curcumin in cocoliposome: In vitro study

Curcumin has been known and used in the medical and industrial world. One way to improve its stability, bioavailability and its medical applications is using encapsulation method. In this research, we studied cocoliposome (coconut liposome) as the encapsulation material. The encapsulation efficiency...

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Autores principales:	Hudiyanti Dwi, Al Khafiz Muhammad Fuad, Anam Khairul, Siahaan Parsaoran, Suyati Linda
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	coconut curcuma longa drug delivery liposome phospholipid Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/cf1e244d02b54f6683e0cbc8cda290d6
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spelling	oai:doaj.org-article:cf1e244d02b54f6683e0cbc8cda290d62021-12-05T14:10:43ZAssessing encapsulation of curcumin in cocoliposome: In vitro study2391-542010.1515/chem-2021-0036https://doaj.org/article/cf1e244d02b54f6683e0cbc8cda290d62021-03-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0036https://doaj.org/toc/2391-5420Curcumin has been known and used in the medical and industrial world. One way to improve its stability, bioavailability and its medical applications is using encapsulation method. In this research, we studied cocoliposome (coconut liposome) as the encapsulation material. The encapsulation efficiency (EE), loading capacity (LC), release rate (RR), as well as the free radical scavenging activity, measured by inhibition ratio (IR), of curcumin in encapsulation product were studied on varying cholesterol compositions and in simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.4) conditions. We found that curcumin encapsulation in cocoliposome (CCL) formulation was influenced by cholesterol composition and pH conditions. The EE, LC and free radical scavenging activity diminished under both the SIF and SGF conditions when the cholesterol concentration enhanced. However, the RR increased as the cholesterol intensified. The condition to acquire the most favorable encapsulation parameter values was at 10% cholesterol composition. Furthermore, the IR results at 10% cholesterol concentration of CCL was 67.70 and 82.13% in SGF and SIF milieu, respectively. The CCL formulation thrived better under SIF conditions for free radical scavenging activities.Hudiyanti DwiAl Khafiz Muhammad FuadAnam KhairulSiahaan ParsaoranSuyati LindaDe Gruyterarticlecoconutcurcuma longadrug deliveryliposomephospholipidChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 358-366 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coconut curcuma longa drug delivery liposome phospholipid Chemistry QD1-999
spellingShingle	coconut curcuma longa drug delivery liposome phospholipid Chemistry QD1-999 Hudiyanti Dwi Al Khafiz Muhammad Fuad Anam Khairul Siahaan Parsaoran Suyati Linda Assessing encapsulation of curcumin in cocoliposome: In vitro study
description	Curcumin has been known and used in the medical and industrial world. One way to improve its stability, bioavailability and its medical applications is using encapsulation method. In this research, we studied cocoliposome (coconut liposome) as the encapsulation material. The encapsulation efficiency (EE), loading capacity (LC), release rate (RR), as well as the free radical scavenging activity, measured by inhibition ratio (IR), of curcumin in encapsulation product were studied on varying cholesterol compositions and in simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.4) conditions. We found that curcumin encapsulation in cocoliposome (CCL) formulation was influenced by cholesterol composition and pH conditions. The EE, LC and free radical scavenging activity diminished under both the SIF and SGF conditions when the cholesterol concentration enhanced. However, the RR increased as the cholesterol intensified. The condition to acquire the most favorable encapsulation parameter values was at 10% cholesterol composition. Furthermore, the IR results at 10% cholesterol concentration of CCL was 67.70 and 82.13% in SGF and SIF milieu, respectively. The CCL formulation thrived better under SIF conditions for free radical scavenging activities.
format	article
author	Hudiyanti Dwi Al Khafiz Muhammad Fuad Anam Khairul Siahaan Parsaoran Suyati Linda
author_facet	Hudiyanti Dwi Al Khafiz Muhammad Fuad Anam Khairul Siahaan Parsaoran Suyati Linda
author_sort	Hudiyanti Dwi
title	Assessing encapsulation of curcumin in cocoliposome: In vitro study
title_short	Assessing encapsulation of curcumin in cocoliposome: In vitro study
title_full	Assessing encapsulation of curcumin in cocoliposome: In vitro study
title_fullStr	Assessing encapsulation of curcumin in cocoliposome: In vitro study
title_full_unstemmed	Assessing encapsulation of curcumin in cocoliposome: In vitro study
title_sort	assessing encapsulation of curcumin in cocoliposome: in vitro study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/cf1e244d02b54f6683e0cbc8cda290d6
work_keys_str_mv	AT hudiyantidwi assessingencapsulationofcurcuminincocoliposomeinvitrostudy AT alkhafizmuhammadfuad assessingencapsulationofcurcuminincocoliposomeinvitrostudy AT anamkhairul assessingencapsulationofcurcuminincocoliposomeinvitrostudy AT siahaanparsaoran assessingencapsulationofcurcuminincocoliposomeinvitrostudy AT suyatilinda assessingencapsulationofcurcuminincocoliposomeinvitrostudy
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Assessing encapsulation of curcumin in cocoliposome: In vitro study

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