Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers

Nguyen Hoai An Le,1 Hoang Van Phan,1 Jiaqi Yu,2 Hak-Kim Chan,2 Adrian Neild,1 Tuncay Alan1 1Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 2The Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Background: This a...

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Autores principales:	Le NHA, Phan HV, Yu J, Chan HK, Neild A, Alan T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Microfluidics nanodrugs budesonide liquid-anti-solvent Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cf200cdf3ac9418690efed96b04806ba
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spelling	oai:doaj.org-article:cf200cdf3ac9418690efed96b04806ba2021-12-02T02:27:05ZAcoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers1178-2013https://doaj.org/article/cf200cdf3ac9418690efed96b04806ba2018-03-01T00:00:00Zhttps://www.dovepress.com/acoustically-enhanced-microfluidic-mixer-to-synthesize-highly-uniform--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nguyen Hoai An Le,1 Hoang Van Phan,1 Jiaqi Yu,2 Hak-Kim Chan,2 Adrian Neild,1 Tuncay Alan1 1Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 2The Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques.Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 µm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles.Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044.Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers. Keywords: microfluidics, nanodrugs, budesonide, liquid antisolvent methodLe NHAPhan HVYu JChan HKNeild AAlan TDove Medical PressarticleMicrofluidicsnanodrugsbudesonideliquid-anti-solventMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1353-1359 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microfluidics nanodrugs budesonide liquid-anti-solvent Medicine (General) R5-920
spellingShingle	Microfluidics nanodrugs budesonide liquid-anti-solvent Medicine (General) R5-920 Le NHA Phan HV Yu J Chan HK Neild A Alan T Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
description	Nguyen Hoai An Le,1 Hoang Van Phan,1 Jiaqi Yu,2 Hak-Kim Chan,2 Adrian Neild,1 Tuncay Alan1 1Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, 2The Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques.Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 µm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles.Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044.Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers. Keywords: microfluidics, nanodrugs, budesonide, liquid antisolvent method
format	article
author	Le NHA Phan HV Yu J Chan HK Neild A Alan T
author_facet	Le NHA Phan HV Yu J Chan HK Neild A Alan T
author_sort	Le NHA
title	Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
title_short	Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
title_full	Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
title_fullStr	Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
title_full_unstemmed	Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
title_sort	acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/cf200cdf3ac9418690efed96b04806ba
work_keys_str_mv	AT lenha acousticallyenhancedmicrofluidicmixertosynthesizehighlyuniformnanodrugswithouttheadditionofstabilizers AT phanhv acousticallyenhancedmicrofluidicmixertosynthesizehighlyuniformnanodrugswithouttheadditionofstabilizers AT yuj acousticallyenhancedmicrofluidicmixertosynthesizehighlyuniformnanodrugswithouttheadditionofstabilizers AT chanhk acousticallyenhancedmicrofluidicmixertosynthesizehighlyuniformnanodrugswithouttheadditionofstabilizers AT neilda acousticallyenhancedmicrofluidicmixertosynthesizehighlyuniformnanodrugswithouttheadditionofstabilizers AT alant acousticallyenhancedmicrofluidicmixertosynthesizehighlyuniformnanodrugswithouttheadditionofstabilizers
_version_	1718402495833702400

Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers

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