Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.

The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes t...

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Autores principales:	Alice G Cheng, Molly McAdow, Hwan K Kim, Taeok Bae, Dominique M Missiakas, Olaf Schneewind
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cf2174806cf741cf9ce7de980c821389
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spelling	oai:doaj.org-article:cf2174806cf741cf9ce7de980c8213892021-11-18T06:01:46ZContribution of coagulases towards Staphylococcus aureus disease and protective immunity.1553-73661553-737410.1371/journal.ppat.1001036https://doaj.org/article/cf2174806cf741cf9ce7de980c8213892010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20700445/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited with specific antibody against each of these molecules. Coa and vWbp specific antibodies confer protection against abscess formation and S. aureus lethal bacteremia, suggesting that coagulases function as protective antigens for a staphylococcal vaccine.Alice G ChengMolly McAdowHwan K KimTaeok BaeDominique M MissiakasOlaf SchneewindPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 8, p e1001036 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Alice G Cheng Molly McAdow Hwan K Kim Taeok Bae Dominique M Missiakas Olaf Schneewind Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
description	The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited with specific antibody against each of these molecules. Coa and vWbp specific antibodies confer protection against abscess formation and S. aureus lethal bacteremia, suggesting that coagulases function as protective antigens for a staphylococcal vaccine.
format	article
author	Alice G Cheng Molly McAdow Hwan K Kim Taeok Bae Dominique M Missiakas Olaf Schneewind
author_facet	Alice G Cheng Molly McAdow Hwan K Kim Taeok Bae Dominique M Missiakas Olaf Schneewind
author_sort	Alice G Cheng
title	Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
title_short	Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
title_full	Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
title_fullStr	Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
title_full_unstemmed	Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.
title_sort	contribution of coagulases towards staphylococcus aureus disease and protective immunity.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/cf2174806cf741cf9ce7de980c821389
work_keys_str_mv	AT alicegcheng contributionofcoagulasestowardsstaphylococcusaureusdiseaseandprotectiveimmunity AT mollymcadow contributionofcoagulasestowardsstaphylococcusaureusdiseaseandprotectiveimmunity AT hwankkim contributionofcoagulasestowardsstaphylococcusaureusdiseaseandprotectiveimmunity AT taeokbae contributionofcoagulasestowardsstaphylococcusaureusdiseaseandprotectiveimmunity AT dominiquemmissiakas contributionofcoagulasestowardsstaphylococcusaureusdiseaseandprotectiveimmunity AT olafschneewind contributionofcoagulasestowardsstaphylococcusaureusdiseaseandprotectiveimmunity
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Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.

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