Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

Via the target-directed miRNA degradation process, RNAs can induce degradation of miRNAs by binding with extensive complementarity. Here, the authors show Serpine1 mRNA as one such RNA that can control the levels of the endogenous miRNA miR-30b/c-5p by modulating miRNA degradation.

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Autores principales:	Francesco Ghini, Carmela Rubolino, Montserrat Climent, Ines Simeone, Matteo J. Marzi, Francesco Nicassio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf2302bea9c84882a186e1c675a3a42a
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spelling	oai:doaj.org-article:cf2302bea9c84882a186e1c675a3a42a2021-12-02T14:39:45ZEndogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation10.1038/s41467-018-05182-92041-1723https://doaj.org/article/cf2302bea9c84882a186e1c675a3a42a2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05182-9https://doaj.org/toc/2041-1723Via the target-directed miRNA degradation process, RNAs can induce degradation of miRNAs by binding with extensive complementarity. Here, the authors show Serpine1 mRNA as one such RNA that can control the levels of the endogenous miRNA miR-30b/c-5p by modulating miRNA degradation.Francesco GhiniCarmela RubolinoMontserrat ClimentInes SimeoneMatteo J. MarziFrancesco NicassioNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesco Ghini Carmela Rubolino Montserrat Climent Ines Simeone Matteo J. Marzi Francesco Nicassio Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
description	Via the target-directed miRNA degradation process, RNAs can induce degradation of miRNAs by binding with extensive complementarity. Here, the authors show Serpine1 mRNA as one such RNA that can control the levels of the endogenous miRNA miR-30b/c-5p by modulating miRNA degradation.
format	article
author	Francesco Ghini Carmela Rubolino Montserrat Climent Ines Simeone Matteo J. Marzi Francesco Nicassio
author_facet	Francesco Ghini Carmela Rubolino Montserrat Climent Ines Simeone Matteo J. Marzi Francesco Nicassio
author_sort	Francesco Ghini
title	Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
title_short	Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
title_full	Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
title_fullStr	Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
title_full_unstemmed	Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
title_sort	endogenous transcripts control mirna levels and activity in mammalian cells by target-directed mirna degradation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cf2302bea9c84882a186e1c675a3a42a
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Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

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