CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY

It has been shown that the influence of hormonal and non-hormonal therapy of menopausal syndrome upon immune profile may be variable, and the results of appropriate studies may be often contradictory. The aim of this work was to investigate the influence of hormonal and non-hormonal therapy in menop...

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Autores principales:	V. N. Zorina, O. V. Isakova, R. M. Zorina, L. G. Bazhenova, N. A. Zorin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	alpha2-macroglobulin pregnancy associated alpha-2-glycoprotein vegf cytokines menopausal hormonal therapy genistein Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cf246ee8d3ee4056b7b5ff9cc35875cd
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spelling	oai:doaj.org-article:cf246ee8d3ee4056b7b5ff9cc35875cd2021-11-18T08:03:45ZCONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY1563-06252313-741X10.15789/1563-0625-2016-2-177-182https://doaj.org/article/cf246ee8d3ee4056b7b5ff9cc35875cd2016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1001https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIt has been shown that the influence of hormonal and non-hormonal therapy of menopausal syndrome upon immune profile may be variable, and the results of appropriate studies may be often contradictory. The aim of this work was to investigate the influence of hormonal and non-hormonal therapy in menopausal syndrome upon serum levels of some immunoregulatory proteins, i.e., alpha2-macroglobulin (a2-MG), pregnancy-associated alpha 2-glycoprotein (PAG), contents of some related cytokines (IL-6, IL-8, TNFα, IFNγ, IL-2) as well as VEGF amounts. Administration of menopausal hormone treatment and nonhormonal therapy was associated with reduced IL-6 levels in serum, regardless of treatment duration, or type of drug applied. We have found a statistically significant decrease of IL-8 serum levels in the course of dynamic monitoring in the women taking a menopausal hormone preparation containing 1 mg of 17β-estradiol and 5 mg dydrogesterone, and a non-hormonal drug containing genistein (60 mg) for 3-6 months. The levels of VEGF demonstrated high individual variability during therapy of menopausal syndrome. Serum concentrations of immunoregulatory a2-MG were stable in climacteric syndrome, and did not differ from normal values. However, the content of PAG, a known immunosuppressive protein, was increased 3-4 times in serum of 33-50% of the women receiving menopausal hormonal therapy, regardless of progestogen dose (5 or 10 mg dydrogesterone), and duration of its use. These findings suggest a need for individualized drug selection in order to minimize a risk of immunodeficiency conditions in the patients receiving hormone therapy of menopausal syndrome.V. N. ZorinaO. V. IsakovaR. M. ZorinaL. G. BazhenovaN. A. ZorinSPb RAACIarticlealpha2-macroglobulinpregnancy associated alpha-2-glycoproteinvegfcytokinesmenopausal hormonal therapygenisteinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 2, Pp 177-182 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	alpha2-macroglobulin pregnancy associated alpha-2-glycoprotein vegf cytokines menopausal hormonal therapy genistein Immunologic diseases. Allergy RC581-607
spellingShingle	alpha2-macroglobulin pregnancy associated alpha-2-glycoprotein vegf cytokines menopausal hormonal therapy genistein Immunologic diseases. Allergy RC581-607 V. N. Zorina O. V. Isakova R. M. Zorina L. G. Bazhenova N. A. Zorin CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY
description	It has been shown that the influence of hormonal and non-hormonal therapy of menopausal syndrome upon immune profile may be variable, and the results of appropriate studies may be often contradictory. The aim of this work was to investigate the influence of hormonal and non-hormonal therapy in menopausal syndrome upon serum levels of some immunoregulatory proteins, i.e., alpha2-macroglobulin (a2-MG), pregnancy-associated alpha 2-glycoprotein (PAG), contents of some related cytokines (IL-6, IL-8, TNFα, IFNγ, IL-2) as well as VEGF amounts. Administration of menopausal hormone treatment and nonhormonal therapy was associated with reduced IL-6 levels in serum, regardless of treatment duration, or type of drug applied. We have found a statistically significant decrease of IL-8 serum levels in the course of dynamic monitoring in the women taking a menopausal hormone preparation containing 1 mg of 17β-estradiol and 5 mg dydrogesterone, and a non-hormonal drug containing genistein (60 mg) for 3-6 months. The levels of VEGF demonstrated high individual variability during therapy of menopausal syndrome. Serum concentrations of immunoregulatory a2-MG were stable in climacteric syndrome, and did not differ from normal values. However, the content of PAG, a known immunosuppressive protein, was increased 3-4 times in serum of 33-50% of the women receiving menopausal hormonal therapy, regardless of progestogen dose (5 or 10 mg dydrogesterone), and duration of its use. These findings suggest a need for individualized drug selection in order to minimize a risk of immunodeficiency conditions in the patients receiving hormone therapy of menopausal syndrome.
format	article
author	V. N. Zorina O. V. Isakova R. M. Zorina L. G. Bazhenova N. A. Zorin
author_facet	V. N. Zorina O. V. Isakova R. M. Zorina L. G. Bazhenova N. A. Zorin
author_sort	V. N. Zorina
title	CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY
title_short	CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY
title_full	CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY
title_fullStr	CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY
title_full_unstemmed	CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY
title_sort	concentrations of immunoregulatory proteins and some cytokines in blood of women during menopausal therapy
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/cf246ee8d3ee4056b7b5ff9cc35875cd
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CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY

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