HIV-1 autologous antibody neutralization associates with mother to child transmission.

The HIV-1 characteristics associated with mother to child transmission (MTCT) are still poorly understood and if known would indicate where intervention strategies should be targeted. In contrast to horizontally infected individuals, exposed infants possess inherited antibodies (Abs) from their moth...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elly Baan, Anthony de Ronde, Martijn Stax, Rogier W Sanders, Stanley Luchters, Joseph Vyankandondera, Joep M Lange, Georgios Pollakis, William A Paxton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf260c6836c2415d98913ad03572b814
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf260c6836c2415d98913ad03572b814
record_format	dspace
spelling	oai:doaj.org-article:cf260c6836c2415d98913ad03572b8142021-11-18T07:37:21ZHIV-1 autologous antibody neutralization associates with mother to child transmission.1932-620310.1371/journal.pone.0069274https://doaj.org/article/cf260c6836c2415d98913ad03572b8142013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874931/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The HIV-1 characteristics associated with mother to child transmission (MTCT) are still poorly understood and if known would indicate where intervention strategies should be targeted. In contrast to horizontally infected individuals, exposed infants possess inherited antibodies (Abs) from their mother with the potential to protect against infection. We investigated the HIV-1 gp160 envelope proteins from seven transmitting mothers (TM) whose children were infected either during gestation or soon after delivery and from four non-transmitting mothers (NTM) with similar viral loads and CD4 counts. Using pseudo-typed viruses we tested gp160 envelope glycoproteins for TZM-bl infectivity, CD4 and CCR5 interactions, DC-SIGN capture and transfer and neutralization with an array of common neutralizing Abs (NAbs) (2F5, 2G12, 4E10 and b12) as well as mother and infant plasma. We found no viral correlates associated with HIV-1 MTCT nor did we find differences in neutralization with the panel of NAbs. We did, however, find that TM possessed significantly higher plasma neutralization capacities than NTM (P = 0.002). Furthermore, we found that in utero (IU) TM had a higher neutralization capacity than mothers transmitting either peri - partum (PP) or via breastfeeding (BF) (P = 0.002). Plasma from children infected IU neutralized viruses carrying autologous gp160 viral envelopes as well as those from their corresponding mothers whilst plasma from children infected PP and/or BF demonstrated poor neutralizing capacity. Our results demonstrate heightened autologous NAb responses against gp120/gp41 can associate with a greater risk of HIV-1 MTCT and more specifically in those infants infected IU. Although the number of HIV-1 transmitting pairs is low our results indicate that autologous NAb responses in mothers and infants do not protect against MTCT and may in fact be detrimental when considering IU HIV-1 transmissions.Elly BaanAnthony de RondeMartijn StaxRogier W SandersStanley LuchtersJoseph VyankandonderaJoep M LangeGeorgios PollakisWilliam A PaxtonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69274 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elly Baan Anthony de Ronde Martijn Stax Rogier W Sanders Stanley Luchters Joseph Vyankandondera Joep M Lange Georgios Pollakis William A Paxton HIV-1 autologous antibody neutralization associates with mother to child transmission.
description	The HIV-1 characteristics associated with mother to child transmission (MTCT) are still poorly understood and if known would indicate where intervention strategies should be targeted. In contrast to horizontally infected individuals, exposed infants possess inherited antibodies (Abs) from their mother with the potential to protect against infection. We investigated the HIV-1 gp160 envelope proteins from seven transmitting mothers (TM) whose children were infected either during gestation or soon after delivery and from four non-transmitting mothers (NTM) with similar viral loads and CD4 counts. Using pseudo-typed viruses we tested gp160 envelope glycoproteins for TZM-bl infectivity, CD4 and CCR5 interactions, DC-SIGN capture and transfer and neutralization with an array of common neutralizing Abs (NAbs) (2F5, 2G12, 4E10 and b12) as well as mother and infant plasma. We found no viral correlates associated with HIV-1 MTCT nor did we find differences in neutralization with the panel of NAbs. We did, however, find that TM possessed significantly higher plasma neutralization capacities than NTM (P = 0.002). Furthermore, we found that in utero (IU) TM had a higher neutralization capacity than mothers transmitting either peri - partum (PP) or via breastfeeding (BF) (P = 0.002). Plasma from children infected IU neutralized viruses carrying autologous gp160 viral envelopes as well as those from their corresponding mothers whilst plasma from children infected PP and/or BF demonstrated poor neutralizing capacity. Our results demonstrate heightened autologous NAb responses against gp120/gp41 can associate with a greater risk of HIV-1 MTCT and more specifically in those infants infected IU. Although the number of HIV-1 transmitting pairs is low our results indicate that autologous NAb responses in mothers and infants do not protect against MTCT and may in fact be detrimental when considering IU HIV-1 transmissions.
format	article
author	Elly Baan Anthony de Ronde Martijn Stax Rogier W Sanders Stanley Luchters Joseph Vyankandondera Joep M Lange Georgios Pollakis William A Paxton
author_facet	Elly Baan Anthony de Ronde Martijn Stax Rogier W Sanders Stanley Luchters Joseph Vyankandondera Joep M Lange Georgios Pollakis William A Paxton
author_sort	Elly Baan
title	HIV-1 autologous antibody neutralization associates with mother to child transmission.
title_short	HIV-1 autologous antibody neutralization associates with mother to child transmission.
title_full	HIV-1 autologous antibody neutralization associates with mother to child transmission.
title_fullStr	HIV-1 autologous antibody neutralization associates with mother to child transmission.
title_full_unstemmed	HIV-1 autologous antibody neutralization associates with mother to child transmission.
title_sort	hiv-1 autologous antibody neutralization associates with mother to child transmission.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cf260c6836c2415d98913ad03572b814
work_keys_str_mv	AT ellybaan hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT anthonyderonde hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT martijnstax hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT rogierwsanders hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT stanleyluchters hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT josephvyankandondera hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT joepmlange hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT georgiospollakis hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission AT williamapaxton hiv1autologousantibodyneutralizationassociateswithmothertochildtransmission
_version_	1718423190260154368

HIV-1 autologous antibody neutralization associates with mother to child transmission.

Ejemplares similares