Acquired cystic fibrosis transmembrane conductance regulator dysfunction

Sinonasal respiratory epithelium is a highly regulated barrier that employs mucociliary clearance (MCC) as the airways first line of defense. The biological properties of the airway surface liquid (ASL), combined with coordinated ciliary beating, are critical components of the mucociliary apparatus....

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Autores principales:	Catherine Banks, Laura Freeman, Do Yeon Cho, Bradford A. Woodworth
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/cf2aea5468d84241a990994a2e4371e8
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spelling	oai:doaj.org-article:cf2aea5468d84241a990994a2e4371e82021-12-02T13:33:38ZAcquired cystic fibrosis transmembrane conductance regulator dysfunction2095-881110.1016/j.wjorl.2018.09.001https://doaj.org/article/cf2aea5468d84241a990994a2e4371e82018-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881118301434https://doaj.org/toc/2095-8811Sinonasal respiratory epithelium is a highly regulated barrier that employs mucociliary clearance (MCC) as the airways first line of defense. The biological properties of the airway surface liquid (ASL), combined with coordinated ciliary beating, are critical components of the mucociliary apparatus. The ASL volume and viscosity is modulated, in part, by the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR is an anion transporter of chloride (Cl−) and bicarbonate (HCO3−) that is located on the apical surface of respiratory epithelium and exocrine glandular epithelium. Improved understanding of how dysfunction or deficiency of CFTR influences the disease process in both genetically defined cystic fibrosis (CF) and acquired conditions has provided further insight into potential avenues of treatment. This review discusses the latest data regarding acquired CFTR deficiency and use of CFTR specific treatment strategies for CRS and other chronic airway diseases. Keywords: CFTR, Cystic fibrosis, CFTR deficiency, CFTR dysfunction, Chronic sinusitis, Chronic rhinosinusitis, Chronic obstructive pulmonary disease, Tobacco, Hypoxia, Resveratrol, l-ascorbateCatherine BanksLaura FreemanDo Yeon ChoBradford A. WoodworthKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 4, Iss 3, Pp 193-199 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Catherine Banks Laura Freeman Do Yeon Cho Bradford A. Woodworth Acquired cystic fibrosis transmembrane conductance regulator dysfunction
description	Sinonasal respiratory epithelium is a highly regulated barrier that employs mucociliary clearance (MCC) as the airways first line of defense. The biological properties of the airway surface liquid (ASL), combined with coordinated ciliary beating, are critical components of the mucociliary apparatus. The ASL volume and viscosity is modulated, in part, by the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR is an anion transporter of chloride (Cl−) and bicarbonate (HCO3−) that is located on the apical surface of respiratory epithelium and exocrine glandular epithelium. Improved understanding of how dysfunction or deficiency of CFTR influences the disease process in both genetically defined cystic fibrosis (CF) and acquired conditions has provided further insight into potential avenues of treatment. This review discusses the latest data regarding acquired CFTR deficiency and use of CFTR specific treatment strategies for CRS and other chronic airway diseases. Keywords: CFTR, Cystic fibrosis, CFTR deficiency, CFTR dysfunction, Chronic sinusitis, Chronic rhinosinusitis, Chronic obstructive pulmonary disease, Tobacco, Hypoxia, Resveratrol, l-ascorbate
format	article
author	Catherine Banks Laura Freeman Do Yeon Cho Bradford A. Woodworth
author_facet	Catherine Banks Laura Freeman Do Yeon Cho Bradford A. Woodworth
author_sort	Catherine Banks
title	Acquired cystic fibrosis transmembrane conductance regulator dysfunction
title_short	Acquired cystic fibrosis transmembrane conductance regulator dysfunction
title_full	Acquired cystic fibrosis transmembrane conductance regulator dysfunction
title_fullStr	Acquired cystic fibrosis transmembrane conductance regulator dysfunction
title_full_unstemmed	Acquired cystic fibrosis transmembrane conductance regulator dysfunction
title_sort	acquired cystic fibrosis transmembrane conductance regulator dysfunction
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/cf2aea5468d84241a990994a2e4371e8
work_keys_str_mv	AT catherinebanks acquiredcysticfibrosistransmembraneconductanceregulatordysfunction AT laurafreeman acquiredcysticfibrosistransmembraneconductanceregulatordysfunction AT doyeoncho acquiredcysticfibrosistransmembraneconductanceregulatordysfunction AT bradfordawoodworth acquiredcysticfibrosistransmembraneconductanceregulatordysfunction
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Acquired cystic fibrosis transmembrane conductance regulator dysfunction

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