Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea

Abstract The South Korean government effectively contained the coronavirus disease-2019 (COVID-19) outbreak primarily associated with a religious group. We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean cases and the religious group...

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Autores principales:	Jeong-Min Kim, Sung Yong Park, Daesang Lee, Jun-Sub Kim, Youngjoon Park, Jin Gwack, Mi Young Kim, Dong Hyun Song, Seong Tae Jeong, Yoon-Seok Chung, Cheon Kwon Yoo, Ha Youn Lee, Myung-Guk Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf2b7786c36a43bf8d64ba95e472e1bd
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spelling	oai:doaj.org-article:cf2b7786c36a43bf8d64ba95e472e1bd2021-12-02T16:31:14ZGenomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea10.1038/s41598-021-85623-62045-2322https://doaj.org/article/cf2b7786c36a43bf8d64ba95e472e1bd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85623-6https://doaj.org/toc/2045-2322Abstract The South Korean government effectively contained the coronavirus disease-2019 (COVID-19) outbreak primarily associated with a religious group. We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean cases and the religious group outbreak. We assessed the accuracy of genomic investigation by comparing the whole genome sequences with comprehensive contact tracing records. Five transmission clusters were estimated among the 15 initial cases. The six close-contact cases and two potential exposure pairs identified by contact tracing showed two or fewer nucleotide base differences. Additionally, we identified two transmission clusters that were phylogenetically distinct from the initial clusters, sharing common G11083T, G26144T, and C14805T markers. The strain closest to the two additional clusters was identified from a pair of identical sequences isolated from individuals who traveled from Wuhan to Italy. Our findings provide insights into the origins of community spread of COVID-19.Jeong-Min KimSung Yong ParkDaesang LeeJun-Sub KimYoungjoon ParkJin GwackMi Young KimDong Hyun SongSeong Tae JeongYoon-Seok ChungCheon Kwon YooHa Youn LeeMyung-Guk HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeong-Min Kim Sung Yong Park Daesang Lee Jun-Sub Kim Youngjoon Park Jin Gwack Mi Young Kim Dong Hyun Song Seong Tae Jeong Yoon-Seok Chung Cheon Kwon Yoo Ha Youn Lee Myung-Guk Han Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea
description	Abstract The South Korean government effectively contained the coronavirus disease-2019 (COVID-19) outbreak primarily associated with a religious group. We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean cases and the religious group outbreak. We assessed the accuracy of genomic investigation by comparing the whole genome sequences with comprehensive contact tracing records. Five transmission clusters were estimated among the 15 initial cases. The six close-contact cases and two potential exposure pairs identified by contact tracing showed two or fewer nucleotide base differences. Additionally, we identified two transmission clusters that were phylogenetically distinct from the initial clusters, sharing common G11083T, G26144T, and C14805T markers. The strain closest to the two additional clusters was identified from a pair of identical sequences isolated from individuals who traveled from Wuhan to Italy. Our findings provide insights into the origins of community spread of COVID-19.
format	article
author	Jeong-Min Kim Sung Yong Park Daesang Lee Jun-Sub Kim Youngjoon Park Jin Gwack Mi Young Kim Dong Hyun Song Seong Tae Jeong Yoon-Seok Chung Cheon Kwon Yoo Ha Youn Lee Myung-Guk Han
author_facet	Jeong-Min Kim Sung Yong Park Daesang Lee Jun-Sub Kim Youngjoon Park Jin Gwack Mi Young Kim Dong Hyun Song Seong Tae Jeong Yoon-Seok Chung Cheon Kwon Yoo Ha Youn Lee Myung-Guk Han
author_sort	Jeong-Min Kim
title	Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea
title_short	Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea
title_full	Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea
title_fullStr	Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea
title_full_unstemmed	Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea
title_sort	genomic investigation of the coronavirus disease-2019 outbreak in the republic of korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf2b7786c36a43bf8d64ba95e472e1bd
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Genomic investigation of the coronavirus disease-2019 outbreak in the Republic of Korea

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