Trefoil factors share a lectin activity that defines their role in mucus

Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same dis...

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Auteurs principaux:	Michael A. Järvå, James P. Lingford, Alan John, Niccolay Madiedo Soler, Nichollas E. Scott, Ethan D. Goddard-Borger
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/cf2cbf05a6394844b850bf051a2a3963
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id	oai:doaj.org-article:cf2cbf05a6394844b850bf051a2a3963
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spelling	oai:doaj.org-article:cf2cbf05a6394844b850bf051a2a39632021-12-02T17:16:14ZTrefoil factors share a lectin activity that defines their role in mucus10.1038/s41467-020-16223-72041-1723https://doaj.org/article/cf2cbf05a6394844b850bf051a2a39632020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16223-7https://doaj.org/toc/2041-1723Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.Michael A. JärvåJames P. LingfordAlan JohnNiccolay Madiedo SolerNichollas E. ScottEthan D. Goddard-BorgerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael A. Järvå James P. Lingford Alan John Niccolay Madiedo Soler Nichollas E. Scott Ethan D. Goddard-Borger Trefoil factors share a lectin activity that defines their role in mucus
description	Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.
format	article
author	Michael A. Järvå James P. Lingford Alan John Niccolay Madiedo Soler Nichollas E. Scott Ethan D. Goddard-Borger
author_facet	Michael A. Järvå James P. Lingford Alan John Niccolay Madiedo Soler Nichollas E. Scott Ethan D. Goddard-Borger
author_sort	Michael A. Järvå
title	Trefoil factors share a lectin activity that defines their role in mucus
title_short	Trefoil factors share a lectin activity that defines their role in mucus
title_full	Trefoil factors share a lectin activity that defines their role in mucus
title_fullStr	Trefoil factors share a lectin activity that defines their role in mucus
title_full_unstemmed	Trefoil factors share a lectin activity that defines their role in mucus
title_sort	trefoil factors share a lectin activity that defines their role in mucus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cf2cbf05a6394844b850bf051a2a3963
work_keys_str_mv	AT michaelajarva trefoilfactorssharealectinactivitythatdefinestheirroleinmucus AT jamesplingford trefoilfactorssharealectinactivitythatdefinestheirroleinmucus AT alanjohn trefoilfactorssharealectinactivitythatdefinestheirroleinmucus AT niccolaymadiedosoler trefoilfactorssharealectinactivitythatdefinestheirroleinmucus AT nichollasescott trefoilfactorssharealectinactivitythatdefinestheirroleinmucus AT ethandgoddardborger trefoilfactorssharealectinactivitythatdefinestheirroleinmucus
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Trefoil factors share a lectin activity that defines their role in mucus

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