Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.

The effects of stress on the neuroendocrine, central nervous and immune systems are extremely complex. The kynurenine pathway (KP) of the tryptophan metabolism is recognised as a cross-link between the neuroendocrine- and immune systems. However, the effects of acute stress from everyday life on KP...

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Autores principales:	Kyaimon Myint, Kelly Jacobs, Aye Mu Myint, Sau Kuen Lam, Lyndal Henden, See Ziau Hoe, Gilles J Guillemin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf2ea231104c410d9f2ab7ab0e75471c
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spelling	oai:doaj.org-article:cf2ea231104c410d9f2ab7ab0e75471c2021-12-02T20:11:05ZEffects of stress associated with academic examination on the kynurenine pathway profile in healthy students.1932-620310.1371/journal.pone.0252668https://doaj.org/article/cf2ea231104c410d9f2ab7ab0e75471c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252668https://doaj.org/toc/1932-6203The effects of stress on the neuroendocrine, central nervous and immune systems are extremely complex. The kynurenine pathway (KP) of the tryptophan metabolism is recognised as a cross-link between the neuroendocrine- and immune systems. However, the effects of acute stress from everyday life on KP activation have not yet been studied. This study aims to investigate changes in the levels of the KP neuroactive metabolites and cytokines in response to stress triggered by academic examinations. Ninety-two healthy first year medical students benevolently participated in the study. Parameters were measured pre- examination, which is considered to be a high-stress period, and post-examination, as a low-stress period. Stress induced by academic examinations significantly increases the perceived stress scores (p<0.001), serum cortisol levels (p<0.001) and brain-derived neurotrophic factor (BDNF) levels (p<0.01). It decreased IL-10 levels (p<0.05) but had no effect on IL-6 and TNF-alpha levels. Only the KP neuroactive metabolite, 3-hydroxykynurenine (3-HK) significantly increased (p<0.01) in the post-examination period. In addition, the stress scores positively correlated with the levels of cortisol (r2 = 0.297, p<0.01) at post examination. Acute stress triggered by academic examinations increases cortisol and BDNF production and suppresses the anti-inflammatory cytokine, IL-10, but did not increase significantly the levels of other pro-inflammatory cytokines, tryptophan, kynurenine and downstream KP metabolites. The concomitant increased levels of BDNF under the duress of acute examination stress appear to limit the levels pro-inflammatory markers, which may attenuate the action of cortisol and the neuroinflammatory branch of the KP.Kyaimon MyintKelly JacobsAye Mu MyintSau Kuen LamLyndal HendenSee Ziau HoeGilles J GuilleminPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252668 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyaimon Myint Kelly Jacobs Aye Mu Myint Sau Kuen Lam Lyndal Henden See Ziau Hoe Gilles J Guillemin Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
description	The effects of stress on the neuroendocrine, central nervous and immune systems are extremely complex. The kynurenine pathway (KP) of the tryptophan metabolism is recognised as a cross-link between the neuroendocrine- and immune systems. However, the effects of acute stress from everyday life on KP activation have not yet been studied. This study aims to investigate changes in the levels of the KP neuroactive metabolites and cytokines in response to stress triggered by academic examinations. Ninety-two healthy first year medical students benevolently participated in the study. Parameters were measured pre- examination, which is considered to be a high-stress period, and post-examination, as a low-stress period. Stress induced by academic examinations significantly increases the perceived stress scores (p<0.001), serum cortisol levels (p<0.001) and brain-derived neurotrophic factor (BDNF) levels (p<0.01). It decreased IL-10 levels (p<0.05) but had no effect on IL-6 and TNF-alpha levels. Only the KP neuroactive metabolite, 3-hydroxykynurenine (3-HK) significantly increased (p<0.01) in the post-examination period. In addition, the stress scores positively correlated with the levels of cortisol (r2 = 0.297, p<0.01) at post examination. Acute stress triggered by academic examinations increases cortisol and BDNF production and suppresses the anti-inflammatory cytokine, IL-10, but did not increase significantly the levels of other pro-inflammatory cytokines, tryptophan, kynurenine and downstream KP metabolites. The concomitant increased levels of BDNF under the duress of acute examination stress appear to limit the levels pro-inflammatory markers, which may attenuate the action of cortisol and the neuroinflammatory branch of the KP.
format	article
author	Kyaimon Myint Kelly Jacobs Aye Mu Myint Sau Kuen Lam Lyndal Henden See Ziau Hoe Gilles J Guillemin
author_facet	Kyaimon Myint Kelly Jacobs Aye Mu Myint Sau Kuen Lam Lyndal Henden See Ziau Hoe Gilles J Guillemin
author_sort	Kyaimon Myint
title	Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
title_short	Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
title_full	Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
title_fullStr	Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
title_full_unstemmed	Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
title_sort	effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/cf2ea231104c410d9f2ab7ab0e75471c
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Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students.

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