Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

Protein phosphatase 5 (PP5) is expressed in many cell types but its role in cardiomyocytes is unknown. Here the authors show that PP5 binds and dephosphorylates elastic titin in cardiac sarcomeres, and that PP5 is increased in heart failure, reducing cardiomyocyte compliance.

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Autores principales:	Judith Krysiak, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios, Farah Sheikh, Ulrich Gergs, Peter Boknik, Wolfgang A. Linke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf31000b822e4204a0bb95e237b05a56
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spelling	oai:doaj.org-article:cf31000b822e4204a0bb95e237b05a562021-12-02T14:40:44ZProtein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes10.1038/s41467-017-02483-32041-1723https://doaj.org/article/cf31000b822e4204a0bb95e237b05a562018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02483-3https://doaj.org/toc/2041-1723Protein phosphatase 5 (PP5) is expressed in many cell types but its role in cardiomyocytes is unknown. Here the authors show that PP5 binds and dephosphorylates elastic titin in cardiac sarcomeres, and that PP5 is increased in heart failure, reducing cardiomyocyte compliance.Judith KrysiakAndreas UngerLisa BeckendorfNazha HamdaniMarion von Frieling-SalewskyMargaret M. RedfieldCris G. dos RemediosFarah SheikhUlrich GergsPeter BoknikWolfgang A. LinkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Judith Krysiak Andreas Unger Lisa Beckendorf Nazha Hamdani Marion von Frieling-Salewsky Margaret M. Redfield Cris G. dos Remedios Farah Sheikh Ulrich Gergs Peter Boknik Wolfgang A. Linke Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
description	Protein phosphatase 5 (PP5) is expressed in many cell types but its role in cardiomyocytes is unknown. Here the authors show that PP5 binds and dephosphorylates elastic titin in cardiac sarcomeres, and that PP5 is increased in heart failure, reducing cardiomyocyte compliance.
format	article
author	Judith Krysiak Andreas Unger Lisa Beckendorf Nazha Hamdani Marion von Frieling-Salewsky Margaret M. Redfield Cris G. dos Remedios Farah Sheikh Ulrich Gergs Peter Boknik Wolfgang A. Linke
author_facet	Judith Krysiak Andreas Unger Lisa Beckendorf Nazha Hamdani Marion von Frieling-Salewsky Margaret M. Redfield Cris G. dos Remedios Farah Sheikh Ulrich Gergs Peter Boknik Wolfgang A. Linke
author_sort	Judith Krysiak
title	Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
title_short	Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
title_full	Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
title_fullStr	Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
title_full_unstemmed	Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
title_sort	protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cf31000b822e4204a0bb95e237b05a56
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Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

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