The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity

The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity

In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.

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Autores principales: Alexandra Santanach, Enrique Blanco, Hua Jiang, Kelly R. Molloy, Miriam Sansó, John LaCava, Lluis Morey, Luciano Di Croce
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cf337e53504d4dbca5db1c546d985bc4
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spelling oai:doaj.org-article:cf337e53504d4dbca5db1c546d985bc42021-12-02T14:41:59ZThe Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity10.1038/s41467-017-01464-w2041-1723https://doaj.org/article/cf337e53504d4dbca5db1c546d985bc42017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01464-whttps://doaj.org/toc/2041-1723In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.Alexandra SantanachEnrique BlancoHua JiangKelly R. MolloyMiriam SansóJohn LaCavaLluis MoreyLuciano Di CroceNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alexandra Santanach
Enrique Blanco
Hua Jiang
Kelly R. Molloy
Miriam Sansó
John LaCava
Lluis Morey
Luciano Di Croce
The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
description In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.
format article
author Alexandra Santanach
Enrique Blanco
Hua Jiang
Kelly R. Molloy
Miriam Sansó
John LaCava
Lluis Morey
Luciano Di Croce
author_facet Alexandra Santanach
Enrique Blanco
Hua Jiang
Kelly R. Molloy
Miriam Sansó
John LaCava
Lluis Morey
Luciano Di Croce
author_sort Alexandra Santanach
title The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
title_short The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
title_full The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
title_fullStr The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
title_full_unstemmed The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
title_sort polycomb group protein cbx6 is an essential regulator of embryonic stem cell identity
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cf337e53504d4dbca5db1c546d985bc4
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