Bidirectional control of absence seizures by the basal ganglia: a computational evidence.

Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge-basal ganglia....

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Autores principales:	Mingming Chen, Daqing Guo, Tiebin Wang, Wei Jing, Yang Xia, Peng Xu, Cheng Luo, Pedro A Valdes-Sosa, Dezhong Yao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cf340ed2d7614992bf8bf6801ecd0744
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spelling	oai:doaj.org-article:cf340ed2d7614992bf8bf6801ecd07442021-11-18T05:53:04ZBidirectional control of absence seizures by the basal ganglia: a computational evidence.1553-734X1553-735810.1371/journal.pcbi.1003495https://doaj.org/article/cf340ed2d7614992bf8bf6801ecd07442014-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24626189/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge-basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures, but the relevant biophysical mechanisms are still not completely established. Using a biophysically based model, we demonstrate here that the typical absence seizure activities can be controlled and modulated by the direct GABAergic projections from the substantia nigra pars reticulata (SNr) to either the thalamic reticular nucleus (TRN) or the specific relay nuclei (SRN) of thalamus, through different biophysical mechanisms. Under certain conditions, these two types of seizure control are observed to coexist in the same network. More importantly, due to the competition between the inhibitory SNr-TRN and SNr-SRN pathways, we find that both decreasing and increasing the activation of SNr neurons from the normal level may considerably suppress the generation of spike-and-slow wave discharges in the coexistence region. Overall, these results highlight the bidirectional functional roles of basal ganglia in controlling and modulating absence seizures, and might provide novel insights into the therapeutic treatments of this brain disorder.Mingming ChenDaqing GuoTiebin WangWei JingYang XiaPeng XuCheng LuoPedro A Valdes-SosaDezhong YaoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 3, p e1003495 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mingming Chen Daqing Guo Tiebin Wang Wei Jing Yang Xia Peng Xu Cheng Luo Pedro A Valdes-Sosa Dezhong Yao Bidirectional control of absence seizures by the basal ganglia: a computational evidence.
description	Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge-basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures, but the relevant biophysical mechanisms are still not completely established. Using a biophysically based model, we demonstrate here that the typical absence seizure activities can be controlled and modulated by the direct GABAergic projections from the substantia nigra pars reticulata (SNr) to either the thalamic reticular nucleus (TRN) or the specific relay nuclei (SRN) of thalamus, through different biophysical mechanisms. Under certain conditions, these two types of seizure control are observed to coexist in the same network. More importantly, due to the competition between the inhibitory SNr-TRN and SNr-SRN pathways, we find that both decreasing and increasing the activation of SNr neurons from the normal level may considerably suppress the generation of spike-and-slow wave discharges in the coexistence region. Overall, these results highlight the bidirectional functional roles of basal ganglia in controlling and modulating absence seizures, and might provide novel insights into the therapeutic treatments of this brain disorder.
format	article
author	Mingming Chen Daqing Guo Tiebin Wang Wei Jing Yang Xia Peng Xu Cheng Luo Pedro A Valdes-Sosa Dezhong Yao
author_facet	Mingming Chen Daqing Guo Tiebin Wang Wei Jing Yang Xia Peng Xu Cheng Luo Pedro A Valdes-Sosa Dezhong Yao
author_sort	Mingming Chen
title	Bidirectional control of absence seizures by the basal ganglia: a computational evidence.
title_short	Bidirectional control of absence seizures by the basal ganglia: a computational evidence.
title_full	Bidirectional control of absence seizures by the basal ganglia: a computational evidence.
title_fullStr	Bidirectional control of absence seizures by the basal ganglia: a computational evidence.
title_full_unstemmed	Bidirectional control of absence seizures by the basal ganglia: a computational evidence.
title_sort	bidirectional control of absence seizures by the basal ganglia: a computational evidence.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/cf340ed2d7614992bf8bf6801ecd0744
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Bidirectional control of absence seizures by the basal ganglia: a computational evidence.

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