Genistein treatment increases bone mass in obese, hyperglycemic mice

Richard M Michelin,1 Layla Al-Nakkash,2 Tom L Broderick,3 Jeffrey H Plochocki4 1Arizona College of Osteopathic Medicine, 2Department of Physiology, 3Laboratory of Diabetes and Exercise Metabolism, Department of Physiology, 4Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern U...

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Autores principales:	Michelin RM, Al-Nakkash L, Broderick TL, Plochocki JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	obesity hyperglycemia genistein ob/ob mice bone Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/cf34d402de0642e99c1d404633b304c0
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spelling	oai:doaj.org-article:cf34d402de0642e99c1d404633b304c02021-12-02T08:39:10ZGenistein treatment increases bone mass in obese, hyperglycemic mice1178-7007https://doaj.org/article/cf34d402de0642e99c1d404633b304c02016-03-01T00:00:00Zhttps://www.dovepress.com/genistein-treatment-increases-bone-mass-in-obese-hyperglycemic-mice-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Richard M Michelin,1 Layla Al-Nakkash,2 Tom L Broderick,3 Jeffrey H Plochocki4 1Arizona College of Osteopathic Medicine, 2Department of Physiology, 3Laboratory of Diabetes and Exercise Metabolism, Department of Physiology, 4Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA Background: Obesity and type 2 diabetes mellitus are associated with elevated risk of limb bone fracture. Incidences of these conditions are on the rise worldwide. Genistein, a phytoestrogen, has been shown by several studies to demonstrate bone-protective properties and may improve bone health in obese type 2 diabetics. Methods: In this study, we test the effects of genistein treatment on limb bone and growth plate cartilage histomorphometry in obese, hyperglycemic ob/ob mice. Six-week-old ob/ob mice were divided into control and genistein-treated groups. Genistein-treated mice were fed a diet containing 600 mg genistein/kg for a period of 4 weeks. Cross-sectional geometric and histomorphometric analyses were conducted on tibias. Results: Genistein-treated mice remained obese and hyperglycemic. However, histomorphometric comparisons show that genistein-treated mice have greater tibial midshaft diameters and ratios of cortical bone to total tissue area than the controls. Genistein-treated mice also exhibit decreased growth plate thickness of the proximal tibia. Conclusion: Our results indicate that genistein treatment affects bone of the tibial midshaft in the ob/ob mouse, independent of improvements in the hyperglycemic state and body weight. Keywords: obesity, hyperglycemia, genistein, ob/ob mice, boneMichelin RMAl-Nakkash LBroderick TLPlochocki JHDove Medical Pressarticleobesityhyperglycemiagenisteinob/ob miceboneSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 63-70 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity hyperglycemia genistein ob/ob mice bone Specialties of internal medicine RC581-951
spellingShingle	obesity hyperglycemia genistein ob/ob mice bone Specialties of internal medicine RC581-951 Michelin RM Al-Nakkash L Broderick TL Plochocki JH Genistein treatment increases bone mass in obese, hyperglycemic mice
description	Richard M Michelin,1 Layla Al-Nakkash,2 Tom L Broderick,3 Jeffrey H Plochocki4 1Arizona College of Osteopathic Medicine, 2Department of Physiology, 3Laboratory of Diabetes and Exercise Metabolism, Department of Physiology, 4Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA Background: Obesity and type 2 diabetes mellitus are associated with elevated risk of limb bone fracture. Incidences of these conditions are on the rise worldwide. Genistein, a phytoestrogen, has been shown by several studies to demonstrate bone-protective properties and may improve bone health in obese type 2 diabetics. Methods: In this study, we test the effects of genistein treatment on limb bone and growth plate cartilage histomorphometry in obese, hyperglycemic ob/ob mice. Six-week-old ob/ob mice were divided into control and genistein-treated groups. Genistein-treated mice were fed a diet containing 600 mg genistein/kg for a period of 4 weeks. Cross-sectional geometric and histomorphometric analyses were conducted on tibias. Results: Genistein-treated mice remained obese and hyperglycemic. However, histomorphometric comparisons show that genistein-treated mice have greater tibial midshaft diameters and ratios of cortical bone to total tissue area than the controls. Genistein-treated mice also exhibit decreased growth plate thickness of the proximal tibia. Conclusion: Our results indicate that genistein treatment affects bone of the tibial midshaft in the ob/ob mouse, independent of improvements in the hyperglycemic state and body weight. Keywords: obesity, hyperglycemia, genistein, ob/ob mice, bone
format	article
author	Michelin RM Al-Nakkash L Broderick TL Plochocki JH
author_facet	Michelin RM Al-Nakkash L Broderick TL Plochocki JH
author_sort	Michelin RM
title	Genistein treatment increases bone mass in obese, hyperglycemic mice
title_short	Genistein treatment increases bone mass in obese, hyperglycemic mice
title_full	Genistein treatment increases bone mass in obese, hyperglycemic mice
title_fullStr	Genistein treatment increases bone mass in obese, hyperglycemic mice
title_full_unstemmed	Genistein treatment increases bone mass in obese, hyperglycemic mice
title_sort	genistein treatment increases bone mass in obese, hyperglycemic mice
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/cf34d402de0642e99c1d404633b304c0
work_keys_str_mv	AT michelinrm genisteintreatmentincreasesbonemassinobesehyperglycemicmice AT alnakkashl genisteintreatmentincreasesbonemassinobesehyperglycemicmice AT brodericktl genisteintreatmentincreasesbonemassinobesehyperglycemicmice AT plochockijh genisteintreatmentincreasesbonemassinobesehyperglycemicmice
_version_	1718398435313319936

Genistein treatment increases bone mass in obese, hyperglycemic mice

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