Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells

Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by pulses of elevated intracellular Ca2+ initiated by bursts of electrical activity. In parallel with these elect...

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Autores principales:	Isabella Marinelli, Patrick A. Fletcher, Arthur S. Sherman, Leslie S. Satin, Richard Bertram
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolism oscillations calcium bursting insulin Physiology QP1-981
Acceso en línea:	https://doaj.org/article/cf35dd63e9d341c5831c721dd9074995
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spelling	oai:doaj.org-article:cf35dd63e9d341c5831c721dd90749952021-12-03T06:46:27ZSymbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells1664-042X10.3389/fphys.2021.781581https://doaj.org/article/cf35dd63e9d341c5831c721dd90749952021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.781581/fullhttps://doaj.org/toc/1664-042XInsulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by pulses of elevated intracellular Ca2+ initiated by bursts of electrical activity. In parallel with these electrical and Ca2+ oscillations are oscillations in metabolism, and the periods of all of these oscillatory processes are similar. A key question that remains unresolved is whether the electrical oscillations are responsible for the metabolic oscillations via the effects of Ca2+, or whether the metabolic oscillations are responsible for the electrical oscillations due to the effects of ATP on ATP-sensitive ion channels? Mathematical modeling is a useful tool for addressing this and related questions as modeling can aid in the design of well-focused experiments that can test the predictions of particular models and subsequently be used to improve the models in an iterative fashion. In this article, we discuss a recent mathematical model, the Integrated Oscillator Model (IOM), that was the product of many years of development. We use the model to demonstrate that the relationship between calcium and metabolism in beta cells is symbiotic: in some contexts, the electrical oscillations drive the metabolic oscillations, while in other contexts it is the opposite. We provide new insights regarding these results and illustrate that what might at first appear to be contradictory data are actually compatible when viewed holistically with the IOM.Isabella MarinelliPatrick A. FletcherArthur S. ShermanLeslie S. SatinRichard BertramFrontiers Media S.A.articlemetabolismoscillationscalciumburstinginsulinPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolism oscillations calcium bursting insulin Physiology QP1-981
spellingShingle	metabolism oscillations calcium bursting insulin Physiology QP1-981 Isabella Marinelli Patrick A. Fletcher Arthur S. Sherman Leslie S. Satin Richard Bertram Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
description	Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by pulses of elevated intracellular Ca2+ initiated by bursts of electrical activity. In parallel with these electrical and Ca2+ oscillations are oscillations in metabolism, and the periods of all of these oscillatory processes are similar. A key question that remains unresolved is whether the electrical oscillations are responsible for the metabolic oscillations via the effects of Ca2+, or whether the metabolic oscillations are responsible for the electrical oscillations due to the effects of ATP on ATP-sensitive ion channels? Mathematical modeling is a useful tool for addressing this and related questions as modeling can aid in the design of well-focused experiments that can test the predictions of particular models and subsequently be used to improve the models in an iterative fashion. In this article, we discuss a recent mathematical model, the Integrated Oscillator Model (IOM), that was the product of many years of development. We use the model to demonstrate that the relationship between calcium and metabolism in beta cells is symbiotic: in some contexts, the electrical oscillations drive the metabolic oscillations, while in other contexts it is the opposite. We provide new insights regarding these results and illustrate that what might at first appear to be contradictory data are actually compatible when viewed holistically with the IOM.
format	article
author	Isabella Marinelli Patrick A. Fletcher Arthur S. Sherman Leslie S. Satin Richard Bertram
author_facet	Isabella Marinelli Patrick A. Fletcher Arthur S. Sherman Leslie S. Satin Richard Bertram
author_sort	Isabella Marinelli
title	Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
title_short	Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
title_full	Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
title_fullStr	Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
title_full_unstemmed	Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
title_sort	symbiosis of electrical and metabolic oscillations in pancreatic β-cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cf35dd63e9d341c5831c721dd9074995
work_keys_str_mv	AT isabellamarinelli symbiosisofelectricalandmetabolicoscillationsinpancreaticbcells AT patrickafletcher symbiosisofelectricalandmetabolicoscillationsinpancreaticbcells AT arthurssherman symbiosisofelectricalandmetabolicoscillationsinpancreaticbcells AT lesliessatin symbiosisofelectricalandmetabolicoscillationsinpancreaticbcells AT richardbertram symbiosisofelectricalandmetabolicoscillationsinpancreaticbcells
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Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells

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