Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes

Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes

Abstract Diabetes-induced podocyte apoptosis is considered to play a critical role in the pathogenesis of diabetic kidney disease (DKD). We proposed that hyperglycaemia can induce podocyte apoptosis by inhibiting the action of podocyte survival factors, thus inactivating the cellular effects of insu...

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Autores principales: Akira Mima, Toshinori Yasuzawa, Tomomi Nakamura, Shigeru Ueshima
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/cf35ec76020743edad0e0c0bda670a8f
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