Antibacterial composite coatings of MgB2 powders embedded in PVP matrix
Abstract Three commercial powders of MgB2 were tested in vitro by MTS and LDH cytotoxicity tests on the HS27 dermal cell line. Depending on powders, the toxicity concentrations were established in the range of 8.3–33.2 µg/ml. The powder with the lowest toxicity limit was embedded into polyvinylpyrro...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cf366c5d080940dabba1a361faf8d912 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cf366c5d080940dabba1a361faf8d912 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cf366c5d080940dabba1a361faf8d9122021-12-02T15:38:23ZAntibacterial composite coatings of MgB2 powders embedded in PVP matrix10.1038/s41598-021-88885-22045-2322https://doaj.org/article/cf366c5d080940dabba1a361faf8d9122021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88885-2https://doaj.org/toc/2045-2322Abstract Three commercial powders of MgB2 were tested in vitro by MTS and LDH cytotoxicity tests on the HS27 dermal cell line. Depending on powders, the toxicity concentrations were established in the range of 8.3–33.2 µg/ml. The powder with the lowest toxicity limit was embedded into polyvinylpyrrolidone (PVP), a biocompatible and biodegradable polymer, for two different concentrations. The self-replenishing MgB2-PVP composite materials were coated on substrate materials (plastic foil of the reservoir and silicon tubes) composing a commercial urinary catheter. The influence of the PVP-reference and MgB2-PVP novel coatings on the bacterial growth of Staphylococcus aureus ATCC 25923, Enterococcus faecium DMS 13590, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, in planktonic and biofilm state was assessed in vitro at 6, 24, and 48 h of incubation time. The MgB2-PVP coatings are efficient both against planktonic microbes and microbial biofilms. Results open promising applications for the use of MgB2 in the design of anti-infective strategies for different biomedical devices and systems.P. BadicaN. D. BataluM. BurduselM. A. GrigoroscutaG. AldicaM. EnculescuG. Gradisteanu PircalabioruM. PopaL. G. MarutescuB. G. DumitriuL. OlariuA. BicuB. PurcareanuL. OpertiV. BoninoA. AgostinoM. TruccatoM. C. ChifiriucNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q P. Badica N. D. Batalu M. Burdusel M. A. Grigoroscuta G. Aldica M. Enculescu G. Gradisteanu Pircalabioru M. Popa L. G. Marutescu B. G. Dumitriu L. Olariu A. Bicu B. Purcareanu L. Operti V. Bonino A. Agostino M. Truccato M. C. Chifiriuc Antibacterial composite coatings of MgB2 powders embedded in PVP matrix |
| description |
Abstract Three commercial powders of MgB2 were tested in vitro by MTS and LDH cytotoxicity tests on the HS27 dermal cell line. Depending on powders, the toxicity concentrations were established in the range of 8.3–33.2 µg/ml. The powder with the lowest toxicity limit was embedded into polyvinylpyrrolidone (PVP), a biocompatible and biodegradable polymer, for two different concentrations. The self-replenishing MgB2-PVP composite materials were coated on substrate materials (plastic foil of the reservoir and silicon tubes) composing a commercial urinary catheter. The influence of the PVP-reference and MgB2-PVP novel coatings on the bacterial growth of Staphylococcus aureus ATCC 25923, Enterococcus faecium DMS 13590, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, in planktonic and biofilm state was assessed in vitro at 6, 24, and 48 h of incubation time. The MgB2-PVP coatings are efficient both against planktonic microbes and microbial biofilms. Results open promising applications for the use of MgB2 in the design of anti-infective strategies for different biomedical devices and systems. |
| format |
article |
| author |
P. Badica N. D. Batalu M. Burdusel M. A. Grigoroscuta G. Aldica M. Enculescu G. Gradisteanu Pircalabioru M. Popa L. G. Marutescu B. G. Dumitriu L. Olariu A. Bicu B. Purcareanu L. Operti V. Bonino A. Agostino M. Truccato M. C. Chifiriuc |
| author_facet |
P. Badica N. D. Batalu M. Burdusel M. A. Grigoroscuta G. Aldica M. Enculescu G. Gradisteanu Pircalabioru M. Popa L. G. Marutescu B. G. Dumitriu L. Olariu A. Bicu B. Purcareanu L. Operti V. Bonino A. Agostino M. Truccato M. C. Chifiriuc |
| author_sort |
P. Badica |
| title |
Antibacterial composite coatings of MgB2 powders embedded in PVP matrix |
| title_short |
Antibacterial composite coatings of MgB2 powders embedded in PVP matrix |
| title_full |
Antibacterial composite coatings of MgB2 powders embedded in PVP matrix |
| title_fullStr |
Antibacterial composite coatings of MgB2 powders embedded in PVP matrix |
| title_full_unstemmed |
Antibacterial composite coatings of MgB2 powders embedded in PVP matrix |
| title_sort |
antibacterial composite coatings of mgb2 powders embedded in pvp matrix |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/cf366c5d080940dabba1a361faf8d912 |
| work_keys_str_mv |
AT pbadica antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT ndbatalu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT mburdusel antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT magrigoroscuta antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT galdica antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT menculescu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT ggradisteanupircalabioru antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT mpopa antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT lgmarutescu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT bgdumitriu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT lolariu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT abicu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT bpurcareanu antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT loperti antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT vbonino antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT aagostino antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT mtruccato antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix AT mcchifiriuc antibacterialcompositecoatingsofmgb2powdersembeddedinpvpmatrix |
| _version_ |
1718386201096880128 |