Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana

Methods to predict transcription factor binding sites typically focus on sequence motifs without considering DNA shape. Here the authors use a random forest machine learning approach that incorporates DNA shape and improves binding site prediction for Arabidopsis thaliana transcription factors.

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Autores principales:	Janik Sielemann, Donat Wulf, Romy Schmidt, Andrea Bräutigam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf39f456ff7a42b1a4a99eb3f1b5ea9d
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spelling	oai:doaj.org-article:cf39f456ff7a42b1a4a99eb3f1b5ea9d2021-11-14T12:36:14ZLocal DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana10.1038/s41467-021-26819-22041-1723https://doaj.org/article/cf39f456ff7a42b1a4a99eb3f1b5ea9d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26819-2https://doaj.org/toc/2041-1723Methods to predict transcription factor binding sites typically focus on sequence motifs without considering DNA shape. Here the authors use a random forest machine learning approach that incorporates DNA shape and improves binding site prediction for Arabidopsis thaliana transcription factors.Janik SielemannDonat WulfRomy SchmidtAndrea BräutigamNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janik Sielemann Donat Wulf Romy Schmidt Andrea Bräutigam Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana
description	Methods to predict transcription factor binding sites typically focus on sequence motifs without considering DNA shape. Here the authors use a random forest machine learning approach that incorporates DNA shape and improves binding site prediction for Arabidopsis thaliana transcription factors.
format	article
author	Janik Sielemann Donat Wulf Romy Schmidt Andrea Bräutigam
author_facet	Janik Sielemann Donat Wulf Romy Schmidt Andrea Bräutigam
author_sort	Janik Sielemann
title	Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana
title_short	Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana
title_full	Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana
title_fullStr	Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana
title_full_unstemmed	Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana
title_sort	local dna shape is a general principle of transcription factor binding specificity in arabidopsis thaliana
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf39f456ff7a42b1a4a99eb3f1b5ea9d
work_keys_str_mv	AT janiksielemann localdnashapeisageneralprincipleoftranscriptionfactorbindingspecificityinarabidopsisthaliana AT donatwulf localdnashapeisageneralprincipleoftranscriptionfactorbindingspecificityinarabidopsisthaliana AT romyschmidt localdnashapeisageneralprincipleoftranscriptionfactorbindingspecificityinarabidopsisthaliana AT andreabrautigam localdnashapeisageneralprincipleoftranscriptionfactorbindingspecificityinarabidopsisthaliana
_version_	1718429132375719936

Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana

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