Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients

Abstract We investigated cardiovascular outcomes in ischemic stroke patients with newly diagnosed diabetes mellitus (DM) compared with those of patients with previously known DM and no DM using the glycosylated hemoglobin (HbA1c) criteria. The relationship between new DM diagnosis and cardiovascular...

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Autores principales:	Kyung-Hee Cho, Sun U. Kwon, Ji Sung Lee, Sungwook Yu, A-Hyun Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf3f07bcb6f643799439d1c4f0118eb7
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spelling	oai:doaj.org-article:cf3f07bcb6f643799439d1c4f0118eb72021-12-02T17:12:17ZNewly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients10.1038/s41598-021-92349-y2045-2322https://doaj.org/article/cf3f07bcb6f643799439d1c4f0118eb72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92349-yhttps://doaj.org/toc/2045-2322Abstract We investigated cardiovascular outcomes in ischemic stroke patients with newly diagnosed diabetes mellitus (DM) compared with those of patients with previously known DM and no DM using the glycosylated hemoglobin (HbA1c) criteria. The relationship between new DM diagnosis and cardiovascular risk remains unclear to date. We performed post hoc analysis using the data of participants from the Prevention of Cardiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage (PICASSO) trial. Newly diagnosed DM was defined as HbA1c of ≥ 6.5% without known DM history. The outcome was the incidence of composite cardiovascular events, including stroke (ischemic and hemorrhagic), myocardial infarction, and cardiovascular death. In total, 1306 patients were included; 38 patients (2.9%) had newly diagnosed DM; 438 patients (33.5%), known DM; and 830 patients (63.6%), no DM. In patients with newly diagnosed DM, known DM, and no DM, the incidence of ischemic stroke was 8.93, 3.79, and 2.64 per 100 person-years (log-rank test; p = 0.0092), while that of composite cardiovascular events was 8.93, 5.92, and 3.87 per 100 person-years (p = 0.025), respectively. Newly diagnosed DM was an important risk factor for ischemic stroke and composite cardiovascular events after ischemic stroke. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01013532.Kyung-Hee ChoSun U. KwonJi Sung LeeSungwook YuA-Hyun ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyung-Hee Cho Sun U. Kwon Ji Sung Lee Sungwook Yu A-Hyun Cho Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
description	Abstract We investigated cardiovascular outcomes in ischemic stroke patients with newly diagnosed diabetes mellitus (DM) compared with those of patients with previously known DM and no DM using the glycosylated hemoglobin (HbA1c) criteria. The relationship between new DM diagnosis and cardiovascular risk remains unclear to date. We performed post hoc analysis using the data of participants from the Prevention of Cardiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage (PICASSO) trial. Newly diagnosed DM was defined as HbA1c of ≥ 6.5% without known DM history. The outcome was the incidence of composite cardiovascular events, including stroke (ischemic and hemorrhagic), myocardial infarction, and cardiovascular death. In total, 1306 patients were included; 38 patients (2.9%) had newly diagnosed DM; 438 patients (33.5%), known DM; and 830 patients (63.6%), no DM. In patients with newly diagnosed DM, known DM, and no DM, the incidence of ischemic stroke was 8.93, 3.79, and 2.64 per 100 person-years (log-rank test; p = 0.0092), while that of composite cardiovascular events was 8.93, 5.92, and 3.87 per 100 person-years (p = 0.025), respectively. Newly diagnosed DM was an important risk factor for ischemic stroke and composite cardiovascular events after ischemic stroke. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01013532.
format	article
author	Kyung-Hee Cho Sun U. Kwon Ji Sung Lee Sungwook Yu A-Hyun Cho
author_facet	Kyung-Hee Cho Sun U. Kwon Ji Sung Lee Sungwook Yu A-Hyun Cho
author_sort	Kyung-Hee Cho
title	Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
title_short	Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
title_full	Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
title_fullStr	Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
title_full_unstemmed	Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
title_sort	newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf3f07bcb6f643799439d1c4f0118eb7
work_keys_str_mv	AT kyungheecho newlydiagnoseddiabeteshashighriskforcardiovascularoutcomeinischemicstrokepatients AT sunukwon newlydiagnoseddiabeteshashighriskforcardiovascularoutcomeinischemicstrokepatients AT jisunglee newlydiagnoseddiabeteshashighriskforcardiovascularoutcomeinischemicstrokepatients AT sungwookyu newlydiagnoseddiabeteshashighriskforcardiovascularoutcomeinischemicstrokepatients AT ahyuncho newlydiagnoseddiabeteshashighriskforcardiovascularoutcomeinischemicstrokepatients
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Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients

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