Modification of fliposomes with a polycation can enhance the control of pH-induced release

Anastasia Yu Lokova, Olga V Zaborova Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation Purpose: Nowadays, the development of stimuli-sensitive nanocontainers for targeted drug delivery is of great value. Encapsulation of a drug in a pH-sensitive lip...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lokova AY, Zaborova OV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	polylysine polymer-colloid complex stimuli-sensitive nanocontainer pH-sensitivity controllable drug release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cf440e7b8e034d1c8ce716c4444a1efd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf440e7b8e034d1c8ce716c4444a1efd
record_format	dspace
spelling	oai:doaj.org-article:cf440e7b8e034d1c8ce716c4444a1efd2021-12-02T05:47:41ZModification of fliposomes with a polycation can enhance the control of pH-induced release1178-2013https://doaj.org/article/cf440e7b8e034d1c8ce716c4444a1efd2019-02-01T00:00:00Zhttps://www.dovepress.com/modification-of-fliposomes-with-a-polycation-can-enhance-the-control-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Anastasia Yu Lokova, Olga V Zaborova Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation Purpose: Nowadays, the development of stimuli-sensitive nanocontainers for targeted drug delivery is of great value. Encapsulation of a drug in a pH-sensitive liposomal container not only provides protective and transport functions, but also helps to create a system with a controlled release mechanism.Methods: In this study, we investigated the influence of a cationic polypeptide on the pH-induced release of anticancer drug doxorubicin (DXR) from the anionic fliposomes – liposomes consisting of a neutral lipid, an anionic lipid (prone to interact with a polycation), and a lipid trigger (imparting the pH-sensitivity).Results: First, we showed the possibility to control the pH-induced release by the simple modification of the anionic fliposomes with linear polylysine. Second, we optimized the fliposomal composition such that the obtained fliposomes responded to the pH changes only when complexed with the polycation (“turning on” the release). Finally, pH-induced release from the polylysine-modified anionic fliposomes was tested on an anticancer drug DXR.Conclusion: We have succeeded in developing “smart” stimuli-sensitive nanocontainers capable of tunable controlled release of a drug. Moreover, based on the data on release of a low molecular salt, one can predict the release profile of DXR. Keywords: polylysine, polymer–colloid complex, stimuli-sensitive nanocontainer, pH-sensitivity, controllable drug releaseLokova AYZaborova OVDove Medical Pressarticlepolylysinepolymer-colloid complexstimuli-sensitive nanocontainerpH-sensitivitycontrollable drug releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1039-1049 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	polylysine polymer-colloid complex stimuli-sensitive nanocontainer pH-sensitivity controllable drug release Medicine (General) R5-920
spellingShingle	polylysine polymer-colloid complex stimuli-sensitive nanocontainer pH-sensitivity controllable drug release Medicine (General) R5-920 Lokova AY Zaborova OV Modification of fliposomes with a polycation can enhance the control of pH-induced release
description	Anastasia Yu Lokova, Olga V Zaborova Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation Purpose: Nowadays, the development of stimuli-sensitive nanocontainers for targeted drug delivery is of great value. Encapsulation of a drug in a pH-sensitive liposomal container not only provides protective and transport functions, but also helps to create a system with a controlled release mechanism.Methods: In this study, we investigated the influence of a cationic polypeptide on the pH-induced release of anticancer drug doxorubicin (DXR) from the anionic fliposomes – liposomes consisting of a neutral lipid, an anionic lipid (prone to interact with a polycation), and a lipid trigger (imparting the pH-sensitivity).Results: First, we showed the possibility to control the pH-induced release by the simple modification of the anionic fliposomes with linear polylysine. Second, we optimized the fliposomal composition such that the obtained fliposomes responded to the pH changes only when complexed with the polycation (“turning on” the release). Finally, pH-induced release from the polylysine-modified anionic fliposomes was tested on an anticancer drug DXR.Conclusion: We have succeeded in developing “smart” stimuli-sensitive nanocontainers capable of tunable controlled release of a drug. Moreover, based on the data on release of a low molecular salt, one can predict the release profile of DXR. Keywords: polylysine, polymer–colloid complex, stimuli-sensitive nanocontainer, pH-sensitivity, controllable drug release
format	article
author	Lokova AY Zaborova OV
author_facet	Lokova AY Zaborova OV
author_sort	Lokova AY
title	Modification of fliposomes with a polycation can enhance the control of pH-induced release
title_short	Modification of fliposomes with a polycation can enhance the control of pH-induced release
title_full	Modification of fliposomes with a polycation can enhance the control of pH-induced release
title_fullStr	Modification of fliposomes with a polycation can enhance the control of pH-induced release
title_full_unstemmed	Modification of fliposomes with a polycation can enhance the control of pH-induced release
title_sort	modification of fliposomes with a polycation can enhance the control of ph-induced release
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/cf440e7b8e034d1c8ce716c4444a1efd
work_keys_str_mv	AT lokovaay modificationoffliposomeswithapolycationcanenhancethecontrolofphinducedrelease AT zaborovaov modificationoffliposomeswithapolycationcanenhancethecontrolofphinducedrelease
_version_	1718400259044933632

Modification of fliposomes with a polycation can enhance the control of pH-induced release

Ejemplares similares