Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population

Shamira A Perera,1–3 Daniel SW Ting,1,2 Monisha E Nongpiur,1–3 Paul T Chew,3 Maria Cecilia D Aquino,3 Chelvin CA Sng,3 Sue-Wei Ho,1,2 Tin Aung1–3 1Singapore Eye Research Institute, Singapore; 2Singapore National Eye Centre, Singapore; 3Department of Ophthalmology, Yong...

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Autores principales:	Perera SA, Ting DSW, Nongpiur ME, Chew PT, Aquino MCD, Sng CCA, Ho SW, Aung T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Travoprost Punctum Plug Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cf4746c7dc064d499a05bfedfcd92e62
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spelling	oai:doaj.org-article:cf4746c7dc064d499a05bfedfcd92e622021-12-02T03:14:47ZFeasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population1177-5483https://doaj.org/article/cf4746c7dc064d499a05bfedfcd92e622016-04-01T00:00:00Zhttps://www.dovepress.com/feasibility-study-of-sustained-release-travoprost-punctum-plug-for-int-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Shamira A Perera,1–3 Daniel SW Ting,1,2 Monisha E Nongpiur,1–3 Paul T Chew,3 Maria Cecilia D Aquino,3 Chelvin CA Sng,3 Sue-Wei Ho,1,2 Tin Aung1–3 1Singapore Eye Research Institute, Singapore; 2Singapore National Eye Centre, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Purpose: To investigate the efficacy and safety of a punctum plug-based sustained drug release system for a prostaglandin analog, travoprost (OTX-TP), for intraocular pressure (IOP) reduction in an Asian population. Methods: This is an initial feasibility, prospective, single-arm study involving 26 eyes and a bioresorbable punctum plug containing OTX-TP. An OTX-TP was placed in the vertical portion of the superior or inferior canaliculus of patients with primary open-angle glaucoma or ocular hypertension. The main outcome measure was the IOP-lowering efficacy of OTX-TP at 3 (8 am) and 10, 20, and 30 days (8 am, 10 am, and 4 pm), compared to baseline. Results: A total of 26 OTX-TP were inserted for 17 subjects. The mean (standard deviation) age was 57.2 (13.8) years. At 10 days, all plugs were still present, and the IOP reduction from baseline was 6.2 (23%), 5.4 (21%), and 7.5 mmHg (28%) at 8 am, 10 am, and 4 pm, respectively. At 10 days, the mean IOP (standard error of mean) was 21.2 (1.2), 20.4 (0.8), and 19.7 (1.0) at 8 am, 10 am, and 4 pm, respectively, showing no discernible IOP trend during the course of the day. At 30 days, plug retention had declined to 42%, and the overall IOP reduction had decreased to 16%. Conclusion: The sustained-release OTX-TP is able to reduce IOP by 24% (day 10) and 15.6% (day 30), respectively. It is a potentially well-tolerable ocular hypotensive for glaucoma patients with a history of poor compliance. Keywords: ocular hypertension, travoprost, bioresorbable, punctum plug, glaucoma, AsianPerera SATing DSWNongpiur MEChew PTAquino MCDSng CCAHo SWAung TDove Medical PressarticleTravoprostPunctum PlugOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 757-764 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Travoprost Punctum Plug Ophthalmology RE1-994
spellingShingle	Travoprost Punctum Plug Ophthalmology RE1-994 Perera SA Ting DSW Nongpiur ME Chew PT Aquino MCD Sng CCA Ho SW Aung T Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
description	Shamira A Perera,1–3 Daniel SW Ting,1,2 Monisha E Nongpiur,1–3 Paul T Chew,3 Maria Cecilia D Aquino,3 Chelvin CA Sng,3 Sue-Wei Ho,1,2 Tin Aung1–3 1Singapore Eye Research Institute, Singapore; 2Singapore National Eye Centre, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Purpose: To investigate the efficacy and safety of a punctum plug-based sustained drug release system for a prostaglandin analog, travoprost (OTX-TP), for intraocular pressure (IOP) reduction in an Asian population. Methods: This is an initial feasibility, prospective, single-arm study involving 26 eyes and a bioresorbable punctum plug containing OTX-TP. An OTX-TP was placed in the vertical portion of the superior or inferior canaliculus of patients with primary open-angle glaucoma or ocular hypertension. The main outcome measure was the IOP-lowering efficacy of OTX-TP at 3 (8 am) and 10, 20, and 30 days (8 am, 10 am, and 4 pm), compared to baseline. Results: A total of 26 OTX-TP were inserted for 17 subjects. The mean (standard deviation) age was 57.2 (13.8) years. At 10 days, all plugs were still present, and the IOP reduction from baseline was 6.2 (23%), 5.4 (21%), and 7.5 mmHg (28%) at 8 am, 10 am, and 4 pm, respectively. At 10 days, the mean IOP (standard error of mean) was 21.2 (1.2), 20.4 (0.8), and 19.7 (1.0) at 8 am, 10 am, and 4 pm, respectively, showing no discernible IOP trend during the course of the day. At 30 days, plug retention had declined to 42%, and the overall IOP reduction had decreased to 16%. Conclusion: The sustained-release OTX-TP is able to reduce IOP by 24% (day 10) and 15.6% (day 30), respectively. It is a potentially well-tolerable ocular hypotensive for glaucoma patients with a history of poor compliance. Keywords: ocular hypertension, travoprost, bioresorbable, punctum plug, glaucoma, Asian
format	article
author	Perera SA Ting DSW Nongpiur ME Chew PT Aquino MCD Sng CCA Ho SW Aung T
author_facet	Perera SA Ting DSW Nongpiur ME Chew PT Aquino MCD Sng CCA Ho SW Aung T
author_sort	Perera SA
title	Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
title_short	Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
title_full	Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
title_fullStr	Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
title_full_unstemmed	Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population
title_sort	feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an asian population
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/cf4746c7dc064d499a05bfedfcd92e62
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Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population

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