Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes

New technologies based on nanocomposites of biopolymers and nanoparticles inspired by the nature of bone structure have accelerated their application in regenerative medicine, thanks to the introduction of reinforcing properties. Our research incorporated chitosan (CS) covalently crosslinked with gl...

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Autores principales:	Carlos Humberto Valencia-Llano, Moisés A. Solano, Carlos David Grande-Tovar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bone tissue regeneration chitosan nanocomposites critical size defect graphene oxide titanium dioxide nanoparticles Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/cf47900dc3f14e0696789cd9847746df
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spelling	oai:doaj.org-article:cf47900dc3f14e0696789cd9847746df2021-11-25T18:47:51ZNanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes10.3390/polym132238772073-4360https://doaj.org/article/cf47900dc3f14e0696789cd9847746df2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3877https://doaj.org/toc/2073-4360New technologies based on nanocomposites of biopolymers and nanoparticles inspired by the nature of bone structure have accelerated their application in regenerative medicine, thanks to the introduction of reinforcing properties. Our research incorporated chitosan (CS) covalently crosslinked with glutaraldehyde (GLA) beads with graphene oxide (GO) nanosheets, titanium dioxide nanoparticles (TiO<sub>2</sub>), and blackberry processing waste extract (BBE) and evaluated them as partial bone substitutes. Skullbone defects in biomodels filled with the scaffolds showed evidence through light microscopy, scanning electron microscopy, histological studies, soft tissue development with hair recovery, and absence of necrotic areas or aggressive infectious response of the immune system after 90 days of implantation. More interestingly, newly formed bone was evidenced by elemental analysis and Masson trichromacy analysis, which demonstrated a possible osteoinductive effect from the beads using the critical size defect experimental design in the biomodels. The results of this research are auspicious for the development of bone substitutes and evidence that the technologies for tissue regeneration, including chitosan nanocomposites, are beneficial for the adhesion and proliferation of bone cells.Carlos Humberto Valencia-LlanoMoisés A. SolanoCarlos David Grande-TovarMDPI AGarticlebone tissue regenerationchitosan nanocompositescritical size defectgraphene oxidetitanium dioxide nanoparticlesOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3877, p 3877 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone tissue regeneration chitosan nanocomposites critical size defect graphene oxide titanium dioxide nanoparticles Organic chemistry QD241-441
spellingShingle	bone tissue regeneration chitosan nanocomposites critical size defect graphene oxide titanium dioxide nanoparticles Organic chemistry QD241-441 Carlos Humberto Valencia-Llano Moisés A. Solano Carlos David Grande-Tovar Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
description	New technologies based on nanocomposites of biopolymers and nanoparticles inspired by the nature of bone structure have accelerated their application in regenerative medicine, thanks to the introduction of reinforcing properties. Our research incorporated chitosan (CS) covalently crosslinked with glutaraldehyde (GLA) beads with graphene oxide (GO) nanosheets, titanium dioxide nanoparticles (TiO<sub>2</sub>), and blackberry processing waste extract (BBE) and evaluated them as partial bone substitutes. Skullbone defects in biomodels filled with the scaffolds showed evidence through light microscopy, scanning electron microscopy, histological studies, soft tissue development with hair recovery, and absence of necrotic areas or aggressive infectious response of the immune system after 90 days of implantation. More interestingly, newly formed bone was evidenced by elemental analysis and Masson trichromacy analysis, which demonstrated a possible osteoinductive effect from the beads using the critical size defect experimental design in the biomodels. The results of this research are auspicious for the development of bone substitutes and evidence that the technologies for tissue regeneration, including chitosan nanocomposites, are beneficial for the adhesion and proliferation of bone cells.
format	article
author	Carlos Humberto Valencia-Llano Moisés A. Solano Carlos David Grande-Tovar
author_facet	Carlos Humberto Valencia-Llano Moisés A. Solano Carlos David Grande-Tovar
author_sort	Carlos Humberto Valencia-Llano
title	Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
title_short	Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
title_full	Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
title_fullStr	Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
title_full_unstemmed	Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes
title_sort	nanocomposites of chitosan/graphene oxide/titanium dioxide nanoparticles/blackberry waste extract as potential bone substitutes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cf47900dc3f14e0696789cd9847746df
work_keys_str_mv	AT carloshumbertovalenciallano nanocompositesofchitosangrapheneoxidetitaniumdioxidenanoparticlesblackberrywasteextractaspotentialbonesubstitutes AT moisesasolano nanocompositesofchitosangrapheneoxidetitaniumdioxidenanoparticlesblackberrywasteextractaspotentialbonesubstitutes AT carlosdavidgrandetovar nanocompositesofchitosangrapheneoxidetitaniumdioxidenanoparticlesblackberrywasteextractaspotentialbonesubstitutes
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Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes

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