Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.

Cutaneous melanoma is a lethal malignancy that arises spontaneously or via in situ precursor neoplasms. While melanoma in situ and locally invasive malignant melanoma can be cured surgically, these lesions can sometimes be difficult to distinguish from melanocytic nevi. Thus, the identification of h...

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Autores principales:	Jinah Kim, Salma Dabiri, E Scott Seeley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf4e52e9a2854b389d57d1890f7748bc
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spelling	oai:doaj.org-article:cf4e52e9a2854b389d57d1890f7748bc2021-11-18T07:34:29ZPrimary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.1932-620310.1371/journal.pone.0027410https://doaj.org/article/cf4e52e9a2854b389d57d1890f7748bc2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22096570/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cutaneous melanoma is a lethal malignancy that arises spontaneously or via in situ precursor neoplasms. While melanoma in situ and locally invasive malignant melanoma can be cured surgically, these lesions can sometimes be difficult to distinguish from melanocytic nevi. Thus, the identification of histolopathologic or molecular features that distinguish these biologically distinct lesions would represent an important advance. To this end, we determined the abundance of melanocytic primary cilia in a series of 62 cases composed of typical cutaneous melanocytic nevi, melanoma in situ, invasive melanoma, and metastatic melanoma. Primary cilia are sensory organelles that modulate developmental and adaptive signaling and notably, are substantially depleted from the neoplastic epithelium of pancreatic carcinoma at a stage equivalent to melanoma in situ. In this series, we find that while nearly all melanocytes in 22 melanocytic nevi possessed a primary cilium, a near-complete loss of this organelle was observed in 16 cases of melanoma in situ, in 16 unequivocal primary invasive melanomas, and in 8 metastatic tumors, each associated with a cutaneous primary lesion. These findings suggest that the primary cilium may be used to segregate cutaneous invasive melanoma and melanoma in situ from melanocytic nevi. Moreover, they place the loss of an organelle known to regulate oncogenic signaling at an early stage of melanoma development.Jinah KimSalma DabiriE Scott SeeleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27410 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinah Kim Salma Dabiri E Scott Seeley Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
description	Cutaneous melanoma is a lethal malignancy that arises spontaneously or via in situ precursor neoplasms. While melanoma in situ and locally invasive malignant melanoma can be cured surgically, these lesions can sometimes be difficult to distinguish from melanocytic nevi. Thus, the identification of histolopathologic or molecular features that distinguish these biologically distinct lesions would represent an important advance. To this end, we determined the abundance of melanocytic primary cilia in a series of 62 cases composed of typical cutaneous melanocytic nevi, melanoma in situ, invasive melanoma, and metastatic melanoma. Primary cilia are sensory organelles that modulate developmental and adaptive signaling and notably, are substantially depleted from the neoplastic epithelium of pancreatic carcinoma at a stage equivalent to melanoma in situ. In this series, we find that while nearly all melanocytes in 22 melanocytic nevi possessed a primary cilium, a near-complete loss of this organelle was observed in 16 cases of melanoma in situ, in 16 unequivocal primary invasive melanomas, and in 8 metastatic tumors, each associated with a cutaneous primary lesion. These findings suggest that the primary cilium may be used to segregate cutaneous invasive melanoma and melanoma in situ from melanocytic nevi. Moreover, they place the loss of an organelle known to regulate oncogenic signaling at an early stage of melanoma development.
format	article
author	Jinah Kim Salma Dabiri E Scott Seeley
author_facet	Jinah Kim Salma Dabiri E Scott Seeley
author_sort	Jinah Kim
title	Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
title_short	Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
title_full	Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
title_fullStr	Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
title_full_unstemmed	Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
title_sort	primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/cf4e52e9a2854b389d57d1890f7748bc
work_keys_str_mv	AT jinahkim primaryciliumdepletiontypifiescutaneousmelanomainsituandmalignantmelanoma AT salmadabiri primaryciliumdepletiontypifiescutaneousmelanomainsituandmalignantmelanoma AT escottseeley primaryciliumdepletiontypifiescutaneousmelanomainsituandmalignantmelanoma
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Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma.

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