The structure of Zika virus NS5 reveals a conserved domain conformation

The structure of Zika virus NS5 reveals a conserved domain conformation

The recent outbreak of Zika virus is a major worldwide health concern and effective drugs are currently not available. Here the authors present the structure of Zika non-structural protein 5 and identify a potential drug-binding site, which might facilitate the development of novel antivirals.

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Autores principales: Boxiao Wang, Xiao-Feng Tan, Stephanie Thurmond, Zhi-Min Zhang, Asher Lin, Rong Hai, Jikui Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cf4e963abfda47169486b44a57c00ed7
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spelling oai:doaj.org-article:cf4e963abfda47169486b44a57c00ed72021-12-02T14:40:58ZThe structure of Zika virus NS5 reveals a conserved domain conformation10.1038/ncomms147632041-1723https://doaj.org/article/cf4e963abfda47169486b44a57c00ed72017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14763https://doaj.org/toc/2041-1723The recent outbreak of Zika virus is a major worldwide health concern and effective drugs are currently not available. Here the authors present the structure of Zika non-structural protein 5 and identify a potential drug-binding site, which might facilitate the development of novel antivirals.Boxiao WangXiao-Feng TanStephanie ThurmondZhi-Min ZhangAsher LinRong HaiJikui SongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Boxiao Wang
Xiao-Feng Tan
Stephanie Thurmond
Zhi-Min Zhang
Asher Lin
Rong Hai
Jikui Song
The structure of Zika virus NS5 reveals a conserved domain conformation
description The recent outbreak of Zika virus is a major worldwide health concern and effective drugs are currently not available. Here the authors present the structure of Zika non-structural protein 5 and identify a potential drug-binding site, which might facilitate the development of novel antivirals.
format article
author Boxiao Wang
Xiao-Feng Tan
Stephanie Thurmond
Zhi-Min Zhang
Asher Lin
Rong Hai
Jikui Song
author_facet Boxiao Wang
Xiao-Feng Tan
Stephanie Thurmond
Zhi-Min Zhang
Asher Lin
Rong Hai
Jikui Song
author_sort Boxiao Wang
title The structure of Zika virus NS5 reveals a conserved domain conformation
title_short The structure of Zika virus NS5 reveals a conserved domain conformation
title_full The structure of Zika virus NS5 reveals a conserved domain conformation
title_fullStr The structure of Zika virus NS5 reveals a conserved domain conformation
title_full_unstemmed The structure of Zika virus NS5 reveals a conserved domain conformation
title_sort structure of zika virus ns5 reveals a conserved domain conformation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cf4e963abfda47169486b44a57c00ed7
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