PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.

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Autores principales:	Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c
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spelling	oai:doaj.org-article:cf504598ffd644018cbb1c9c1fc2bf2c2021-12-02T14:16:40ZPDX1LOW MAFALOW β-cells contribute to islet function and insulin release10.1038/s41467-020-20632-z2041-1723https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20632-zhttps://doaj.org/toc/2041-1723Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.Daniela NasteskaNicholas H. F. FineFiona B. AshfordFederica CuozzoKatrina ViloriaGabrielle SmithAisha DahirPeter W. J. DawsonYu-Chiang LaiAimée Bastidas-PonceMostafa BakhtiGuy A. RutterRemi FiancetteRita NanoLorenzo PiemontiHeiko LickertQiao ZhouIldem AkermanDavid J. HodsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Nasteska Nicholas H. F. Fine Fiona B. Ashford Federica Cuozzo Katrina Viloria Gabrielle Smith Aisha Dahir Peter W. J. Dawson Yu-Chiang Lai Aimée Bastidas-Ponce Mostafa Bakhti Guy A. Rutter Remi Fiancette Rita Nano Lorenzo Piemonti Heiko Lickert Qiao Zhou Ildem Akerman David J. Hodson PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
description	Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.
format	article
author	Daniela Nasteska Nicholas H. F. Fine Fiona B. Ashford Federica Cuozzo Katrina Viloria Gabrielle Smith Aisha Dahir Peter W. J. Dawson Yu-Chiang Lai Aimée Bastidas-Ponce Mostafa Bakhti Guy A. Rutter Remi Fiancette Rita Nano Lorenzo Piemonti Heiko Lickert Qiao Zhou Ildem Akerman David J. Hodson
author_facet	Daniela Nasteska Nicholas H. F. Fine Fiona B. Ashford Federica Cuozzo Katrina Viloria Gabrielle Smith Aisha Dahir Peter W. J. Dawson Yu-Chiang Lai Aimée Bastidas-Ponce Mostafa Bakhti Guy A. Rutter Remi Fiancette Rita Nano Lorenzo Piemonti Heiko Lickert Qiao Zhou Ildem Akerman David J. Hodson
author_sort	Daniela Nasteska
title	PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
title_short	PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
title_full	PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
title_fullStr	PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
title_full_unstemmed	PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
title_sort	pdx1low mafalow β-cells contribute to islet function and insulin release
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c
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PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

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