Haematological abnormalities in systemic sclerosis

Systemic sclerosis (SSc) is a connective tissue disease characterised by extremely high heterogeneity. This heterogeneity concerns the organ involvement, course of disease and prognosis. Unlike in some other systemic connective tissue diseases, especially systemic lupus erythematosus, in SSc haemato...

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Autores principales:	Ewa Wielosz, Maria Majdan
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2020
Materias:	systemic sclerosis lymphoma haematological abnormalities. Medicine R
Acceso en línea:	https://doaj.org/article/cf52247cdf3944c5a959d18733ad200c
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spelling	oai:doaj.org-article:cf52247cdf3944c5a959d18733ad200c2021-12-02T17:46:04ZHaematological abnormalities in systemic sclerosis0034-62332084-983410.5114/reum.2020.96655https://doaj.org/article/cf52247cdf3944c5a959d18733ad200c2020-06-01T00:00:00Zhttps://www.termedia.pl/Haematological-abnormalities-in-systemic-sclerosis,18,41077,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Systemic sclerosis (SSc) is a connective tissue disease characterised by extremely high heterogeneity. This heterogeneity concerns the organ involvement, course of disease and prognosis. Unlike in some other systemic connective tissue diseases, especially systemic lupus erythematosus, in SSc haematological disorders occur rarely. When they develop, they affect erythrocytes, leucocytes and platelets. The most common cause of this pathology of erythrocyte abnormalities is microcytic anaemia resulting from micro-haemorrhages with telangiectasias within the digestive mucosa in patients with SSc. In SSc patients with severe haematological disturbances, the differential diagnosis should include overlapping with another systemic connective tissue disease or a haemato-oncological disease (lympho/myeloproliferative syndrome). In SSc patients with monoclonal proteins or cryoglobulins, it is essential to consider a haemato-oncological disease. In such cases, the differential diagnosis should be focused on a paraneoplastic syndrome, especially when the haematological symptoms develop shortly after the diagnosis of SSc and in the elderly.Ewa WieloszMaria MajdanTermedia Publishing Housearticlesystemic sclerosis lymphoma haematological abnormalities.MedicineRENRheumatology, Vol 58, Iss 3, Pp 162-166 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic sclerosis lymphoma haematological abnormalities. Medicine R
spellingShingle	systemic sclerosis lymphoma haematological abnormalities. Medicine R Ewa Wielosz Maria Majdan Haematological abnormalities in systemic sclerosis
description	Systemic sclerosis (SSc) is a connective tissue disease characterised by extremely high heterogeneity. This heterogeneity concerns the organ involvement, course of disease and prognosis. Unlike in some other systemic connective tissue diseases, especially systemic lupus erythematosus, in SSc haematological disorders occur rarely. When they develop, they affect erythrocytes, leucocytes and platelets. The most common cause of this pathology of erythrocyte abnormalities is microcytic anaemia resulting from micro-haemorrhages with telangiectasias within the digestive mucosa in patients with SSc. In SSc patients with severe haematological disturbances, the differential diagnosis should include overlapping with another systemic connective tissue disease or a haemato-oncological disease (lympho/myeloproliferative syndrome). In SSc patients with monoclonal proteins or cryoglobulins, it is essential to consider a haemato-oncological disease. In such cases, the differential diagnosis should be focused on a paraneoplastic syndrome, especially when the haematological symptoms develop shortly after the diagnosis of SSc and in the elderly.
format	article
author	Ewa Wielosz Maria Majdan
author_facet	Ewa Wielosz Maria Majdan
author_sort	Ewa Wielosz
title	Haematological abnormalities in systemic sclerosis
title_short	Haematological abnormalities in systemic sclerosis
title_full	Haematological abnormalities in systemic sclerosis
title_fullStr	Haematological abnormalities in systemic sclerosis
title_full_unstemmed	Haematological abnormalities in systemic sclerosis
title_sort	haematological abnormalities in systemic sclerosis
publisher	Termedia Publishing House
publishDate	2020
url	https://doaj.org/article/cf52247cdf3944c5a959d18733ad200c
work_keys_str_mv	AT ewawielosz haematologicalabnormalitiesinsystemicsclerosis AT mariamajdan haematologicalabnormalitiesinsystemicsclerosis
_version_	1718379556336828416

Haematological abnormalities in systemic sclerosis

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