Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy

Abstract Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if...

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Autores principales:	Pablo Torres-Sánchez, Ignacio Porras, Nataliya Ramos-Chernenko, Fernando Arias de Saavedra, Javier Praena
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf555688244c4cc19921d75f5de51149
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spelling	oai:doaj.org-article:cf555688244c4cc19921d75f5de511492021-12-02T18:15:49ZOptimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy10.1038/s41598-021-87305-92045-2322https://doaj.org/article/cf555688244c4cc19921d75f5de511492021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87305-9https://doaj.org/toc/2045-2322Abstract Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.Pablo Torres-SánchezIgnacio PorrasNataliya Ramos-ChernenkoFernando Arias de SaavedraJavier PraenaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pablo Torres-Sánchez Ignacio Porras Nataliya Ramos-Chernenko Fernando Arias de Saavedra Javier Praena Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
description	Abstract Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.
format	article
author	Pablo Torres-Sánchez Ignacio Porras Nataliya Ramos-Chernenko Fernando Arias de Saavedra Javier Praena
author_facet	Pablo Torres-Sánchez Ignacio Porras Nataliya Ramos-Chernenko Fernando Arias de Saavedra Javier Praena
author_sort	Pablo Torres-Sánchez
title	Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_short	Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_full	Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_fullStr	Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_full_unstemmed	Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy
title_sort	optimized beam shaping assembly for a 2.1-mev proton-accelerator-based neutron source for boron neutron capture therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf555688244c4cc19921d75f5de51149
work_keys_str_mv	AT pablotorressanchez optimizedbeamshapingassemblyfora21mevprotonacceleratorbasedneutronsourceforboronneutroncapturetherapy AT ignacioporras optimizedbeamshapingassemblyfora21mevprotonacceleratorbasedneutronsourceforboronneutroncapturetherapy AT nataliyaramoschernenko optimizedbeamshapingassemblyfora21mevprotonacceleratorbasedneutronsourceforboronneutroncapturetherapy AT fernandoariasdesaavedra optimizedbeamshapingassemblyfora21mevprotonacceleratorbasedneutronsourceforboronneutroncapturetherapy AT javierpraena optimizedbeamshapingassemblyfora21mevprotonacceleratorbasedneutronsourceforboronneutroncapturetherapy
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Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy

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