GANAB as a Novel Biomarker in Multiple Sclerosis: Correlation with Neuroinflammation and IFI35
Multiple sclerosis (MS) still lacks reliable biomarkers of neuroinflammation predictive for disease activity and treatment response. Thus, in a prospective study we assessed 55 MS patients (28 interferon (IFN)-treated, 10 treated with no-IFN therapies, 17 untreated) and 20 matched healthy controls (...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/cf5ad9c582db4e58845a5c6cfa3c41cd |
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| Sumario: | Multiple sclerosis (MS) still lacks reliable biomarkers of neuroinflammation predictive for disease activity and treatment response. Thus, in a prospective study we assessed 55 MS patients (28 interferon (IFN)-treated, 10 treated with no-IFN therapies, 17 untreated) and 20 matched healthy controls (HCs) for the putative correlation of the densitometric expression of glucosidase II alpha subunit (GANAB) with clinical/paraclinical parameters and with interferon-induced protein 35 (IFI35). We also assessed the disease progression in terms of the Rio Score (RS) in order to distinguish the responder patients to IFN therapy (RS = 0) from the non-responder ones (RS ≥ 1). We found GANAB to be 2.51-fold downregulated in the IFN-treated group with respect to the untreated one (<i>p</i> < 0.0001) and 3.39-fold downregulated in responder patients compared to the non-responders (<i>p</i> < 0.0001). GANAB correlated directly with RS (r = 0.8088, <i>p</i> < 0.0001) and lesion load (LL) (r = 0.5824, <i>p</i> = 0.0014) in the IFN-treated group and inversely with disease duration (DD) (r = −0.6081, <i>p</i> = 0.0096) in the untreated one. Lower mean values were expressed for GANAB than IFI35 in IFN responder (<i>p</i> < 0.0001) and higher mean values in the non-responder patients (<i>p</i> = 0.0022). Inverse correlations were also expressed with IFI35 in the overall patient population (r = −0.6468, <i>p</i> < 0.0001). In conclusion, the modular expression of GANAB reflects IFI35, RS, DD, and LL values, making it a biomarker of neuroinflammation that is predictive for disease activity and treatment response in MS. |
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