The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection

The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into amphisomes, suggesting these to represent a type of...

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Autores principales: Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Makoto Yamashita, Kiyotaka Nishikawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cf5c2b2aa01a4b1b81e53280acad9dd5
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spelling oai:doaj.org-article:cf5c2b2aa01a4b1b81e53280acad9dd52021-12-02T14:42:15ZThe inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection10.1038/s41467-019-13974-w2041-1723https://doaj.org/article/cf5c2b2aa01a4b1b81e53280acad9dd52020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13974-whttps://doaj.org/toc/2041-1723The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into amphisomes, suggesting these to represent a type of anti-viral machinery.Jumpei OmiMiho Watanabe-TakahashiKatsura IgaiEiko ShimizuChing-Yi TsengTomohiro MiyasakaTsuyoshi WakuShinichiro HamaRieka NakanishiYuki GotoYuri NishinoAtsuo MiyazawaYasuhiro NatoriMakoto YamashitaKiyotaka NishikawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jumpei Omi
Miho Watanabe-Takahashi
Katsura Igai
Eiko Shimizu
Ching-Yi Tseng
Tomohiro Miyasaka
Tsuyoshi Waku
Shinichiro Hama
Rieka Nakanishi
Yuki Goto
Yuri Nishino
Atsuo Miyazawa
Yasuhiro Natori
Makoto Yamashita
Kiyotaka Nishikawa
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
description The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into amphisomes, suggesting these to represent a type of anti-viral machinery.
format article
author Jumpei Omi
Miho Watanabe-Takahashi
Katsura Igai
Eiko Shimizu
Ching-Yi Tseng
Tomohiro Miyasaka
Tsuyoshi Waku
Shinichiro Hama
Rieka Nakanishi
Yuki Goto
Yuri Nishino
Atsuo Miyazawa
Yasuhiro Natori
Makoto Yamashita
Kiyotaka Nishikawa
author_facet Jumpei Omi
Miho Watanabe-Takahashi
Katsura Igai
Eiko Shimizu
Ching-Yi Tseng
Tomohiro Miyasaka
Tsuyoshi Waku
Shinichiro Hama
Rieka Nakanishi
Yuki Goto
Yuri Nishino
Atsuo Miyazawa
Yasuhiro Natori
Makoto Yamashita
Kiyotaka Nishikawa
author_sort Jumpei Omi
title The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
title_short The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
title_full The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
title_fullStr The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
title_full_unstemmed The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
title_sort inducible amphisome isolates viral hemagglutinin and defends against influenza a virus infection
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cf5c2b2aa01a4b1b81e53280acad9dd5
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