APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients

Abstract Obesity is a critical issue in patients with schizophrenia, which is considered to be brought about by both environmental and genetic factors. Apolipoprotein E (APOE) gene polymorphisms might be involved in the pathogenesis of schizophrenia, however, the effect of APOE gene polymorphism on...

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Autores principales:	Wei Li, Fengju Liu, Rui Liu, Xinmei Zhou, Guanjun Li, Shifu Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf64ed9537c5484ab3f30bfa357ecfce
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spelling	oai:doaj.org-article:cf64ed9537c5484ab3f30bfa357ecfce2021-12-02T16:17:17ZAPOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients10.1038/s41598-021-94381-42045-2322https://doaj.org/article/cf64ed9537c5484ab3f30bfa357ecfce2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94381-4https://doaj.org/toc/2045-2322Abstract Obesity is a critical issue in patients with schizophrenia, which is considered to be brought about by both environmental and genetic factors. Apolipoprotein E (APOE) gene polymorphisms might be involved in the pathogenesis of schizophrenia, however, the effect of APOE gene polymorphism on obesity has never been investigated in Chinese aging with schizophrenia. This cross-sectional study was to investigate the effect of obesity on cognitive and psychiatric symptoms in elderly participants with schizophrenia. At the same time, we also discussed the inner link between APOE E4 and obesity. 301 elderly participants with schizophrenia and 156 normal controls were included in the study. Their cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), and APOE gene polymorphism was determined by polymerase chain reaction (PCR). The prevalence of obesity in elderly schizophrenic patients and healthy controls accounted for 15.9% (48/301) and 10.3% (16/156), respectively, with no statistically significant difference. By using stepwise linear regression analysis, we found that elevated fasting blood glucose, hypertension, and hyperlipidemia were risk factors for obesity in elderly schizophrenic patients. Although there was no direct correlation between APOE E4 and obesity in patients with schizophrenia, it was significantly correlated with hyperlipemia(r = − 0.154, p = 0.008), suggesting that APOE E4 may induce obesity in elderly patients with schizophrenia through hyperlipemia, However, the above conclusions do not apply to the normal elderly. What’s more, we did not find a link between obesity and cognitive function or mental symptoms for both patients with schizophrenia and normal controls. APOE E4 is associated with hyperlipidemia in elderly schizophrenic patients, which may be a risk factor for obesity, however, the above conclusion does not apply to the normal elderly.Wei LiFengju LiuRui LiuXinmei ZhouGuanjun LiShifu XiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Li Fengju Liu Rui Liu Xinmei Zhou Guanjun Li Shifu Xiao APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
description	Abstract Obesity is a critical issue in patients with schizophrenia, which is considered to be brought about by both environmental and genetic factors. Apolipoprotein E (APOE) gene polymorphisms might be involved in the pathogenesis of schizophrenia, however, the effect of APOE gene polymorphism on obesity has never been investigated in Chinese aging with schizophrenia. This cross-sectional study was to investigate the effect of obesity on cognitive and psychiatric symptoms in elderly participants with schizophrenia. At the same time, we also discussed the inner link between APOE E4 and obesity. 301 elderly participants with schizophrenia and 156 normal controls were included in the study. Their cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), and APOE gene polymorphism was determined by polymerase chain reaction (PCR). The prevalence of obesity in elderly schizophrenic patients and healthy controls accounted for 15.9% (48/301) and 10.3% (16/156), respectively, with no statistically significant difference. By using stepwise linear regression analysis, we found that elevated fasting blood glucose, hypertension, and hyperlipidemia were risk factors for obesity in elderly schizophrenic patients. Although there was no direct correlation between APOE E4 and obesity in patients with schizophrenia, it was significantly correlated with hyperlipemia(r = − 0.154, p = 0.008), suggesting that APOE E4 may induce obesity in elderly patients with schizophrenia through hyperlipemia, However, the above conclusions do not apply to the normal elderly. What’s more, we did not find a link between obesity and cognitive function or mental symptoms for both patients with schizophrenia and normal controls. APOE E4 is associated with hyperlipidemia in elderly schizophrenic patients, which may be a risk factor for obesity, however, the above conclusion does not apply to the normal elderly.
format	article
author	Wei Li Fengju Liu Rui Liu Xinmei Zhou Guanjun Li Shifu Xiao
author_facet	Wei Li Fengju Liu Rui Liu Xinmei Zhou Guanjun Li Shifu Xiao
author_sort	Wei Li
title	APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
title_short	APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
title_full	APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
title_fullStr	APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
title_full_unstemmed	APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
title_sort	apoe e4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf64ed9537c5484ab3f30bfa357ecfce
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APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients

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