Targeting the HIV-infected brain to improve ischemic stroke outcome

Here, using the EcoHIV mouse model of infection, Bertrand et al. report that HIV infection contributes to ischemic stroke damage and decreased tissue recovery by disrupting blood–brain barrier integrity and show that antivirals with high CNS penetration can reduce tissue injury and accelerate post-s...

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Autores principales:	Luc Bertrand, Fannie Méroth, Marie Tournebize, Ana Rachel Leda, Enze Sun, Michal Toborek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf65a55dbe904114b5bf7a05c1dcb368
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spelling	oai:doaj.org-article:cf65a55dbe904114b5bf7a05c1dcb3682021-12-02T16:57:20ZTargeting the HIV-infected brain to improve ischemic stroke outcome10.1038/s41467-019-10046-x2041-1723https://doaj.org/article/cf65a55dbe904114b5bf7a05c1dcb3682019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10046-xhttps://doaj.org/toc/2041-1723Here, using the EcoHIV mouse model of infection, Bertrand et al. report that HIV infection contributes to ischemic stroke damage and decreased tissue recovery by disrupting blood–brain barrier integrity and show that antivirals with high CNS penetration can reduce tissue injury and accelerate post-stroke recovery.Luc BertrandFannie MérothMarie TournebizeAna Rachel LedaEnze SunMichal ToborekNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luc Bertrand Fannie Méroth Marie Tournebize Ana Rachel Leda Enze Sun Michal Toborek Targeting the HIV-infected brain to improve ischemic stroke outcome
description	Here, using the EcoHIV mouse model of infection, Bertrand et al. report that HIV infection contributes to ischemic stroke damage and decreased tissue recovery by disrupting blood–brain barrier integrity and show that antivirals with high CNS penetration can reduce tissue injury and accelerate post-stroke recovery.
format	article
author	Luc Bertrand Fannie Méroth Marie Tournebize Ana Rachel Leda Enze Sun Michal Toborek
author_facet	Luc Bertrand Fannie Méroth Marie Tournebize Ana Rachel Leda Enze Sun Michal Toborek
author_sort	Luc Bertrand
title	Targeting the HIV-infected brain to improve ischemic stroke outcome
title_short	Targeting the HIV-infected brain to improve ischemic stroke outcome
title_full	Targeting the HIV-infected brain to improve ischemic stroke outcome
title_fullStr	Targeting the HIV-infected brain to improve ischemic stroke outcome
title_full_unstemmed	Targeting the HIV-infected brain to improve ischemic stroke outcome
title_sort	targeting the hiv-infected brain to improve ischemic stroke outcome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cf65a55dbe904114b5bf7a05c1dcb368
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Targeting the HIV-infected brain to improve ischemic stroke outcome

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