Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity

Duffy binding protein (DBP) of Plasmodium vivax is important for invasion and is a potential vaccine candidate. Here, the authors show that PvDBP gene amplification protects P vivax in vitro against invasion inhibitory human monoclonal antibodies and is associated to infection of patients with PvDBP...

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Autores principales:	Jean Popovici, Camille Roesch, Lenore L. Carias, Nimol Khim, Saorin Kim, Amelie Vantaux, Ivo Mueller, Chetan E. Chitnis, Christopher L. King, Benoit Witkowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf65b319fe4a4e48a9d32fb245c93fef
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spelling	oai:doaj.org-article:cf65b319fe4a4e48a9d32fb245c93fef2021-12-02T15:39:22ZAmplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity10.1038/s41467-020-14574-92041-1723https://doaj.org/article/cf65b319fe4a4e48a9d32fb245c93fef2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14574-9https://doaj.org/toc/2041-1723Duffy binding protein (DBP) of Plasmodium vivax is important for invasion and is a potential vaccine candidate. Here, the authors show that PvDBP gene amplification protects P vivax in vitro against invasion inhibitory human monoclonal antibodies and is associated to infection of patients with PvDBP binding inhibitory antibodies.Jean PopoviciCamille RoeschLenore L. CariasNimol KhimSaorin KimAmelie VantauxIvo MuellerChetan E. ChitnisChristopher L. KingBenoit WitkowskiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean Popovici Camille Roesch Lenore L. Carias Nimol Khim Saorin Kim Amelie Vantaux Ivo Mueller Chetan E. Chitnis Christopher L. King Benoit Witkowski Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
description	Duffy binding protein (DBP) of Plasmodium vivax is important for invasion and is a potential vaccine candidate. Here, the authors show that PvDBP gene amplification protects P vivax in vitro against invasion inhibitory human monoclonal antibodies and is associated to infection of patients with PvDBP binding inhibitory antibodies.
format	article
author	Jean Popovici Camille Roesch Lenore L. Carias Nimol Khim Saorin Kim Amelie Vantaux Ivo Mueller Chetan E. Chitnis Christopher L. King Benoit Witkowski
author_facet	Jean Popovici Camille Roesch Lenore L. Carias Nimol Khim Saorin Kim Amelie Vantaux Ivo Mueller Chetan E. Chitnis Christopher L. King Benoit Witkowski
author_sort	Jean Popovici
title	Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
title_short	Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
title_full	Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
title_fullStr	Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
title_full_unstemmed	Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
title_sort	amplification of duffy binding protein-encoding gene allows plasmodium vivax to evade host anti-dbp humoral immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cf65b319fe4a4e48a9d32fb245c93fef
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Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity

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