Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

Background: Malignant odontogenic tumours (MOTs) arise either de novo from the tooth forming tissues, their developmental residues or from existing odontogenic epithelial or mesenchymal neoplasms in the jaws. Their management requires extensive surgery due to their infiltrative nature and risk of me...

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Autores principales:	Constanza Marin, Manas Dave, Keith D. Hunter
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	odontogenic tumour malignant odontogenic tumour radiographic features treatment recurrence Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/cf68e2b02d49458d829f34b33582bd58
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spelling	oai:doaj.org-article:cf68e2b02d49458d829f34b33582bd582021-11-19T06:36:50ZMalignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature2673-484210.3389/froh.2021.775707https://doaj.org/article/cf68e2b02d49458d829f34b33582bd582021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/froh.2021.775707/fullhttps://doaj.org/toc/2673-4842Background: Malignant odontogenic tumours (MOTs) arise either de novo from the tooth forming tissues, their developmental residues or from existing odontogenic epithelial or mesenchymal neoplasms in the jaws. Their management requires extensive surgery due to their infiltrative nature and risk of metastasis. There is a need to understand the clinical and pathological features of MOTs to inform both treatment algorithms and prognostication. This is an area of diagnostic pathology which presents substantial difficulties in diagnosis, compounded by inconsistent use of terminology. Thus, this systematic review aimed to describe the clinical and pathological features of MOTs with a view to consolidating the literature and defining problematic areas in diagnosis and classification.Methods: An electronic database search was conducted in Web of Science, PubMed/Medline, and Embase. Additionally, the grey literature and reference lists of selected papers searched for completeness. Nine hundred and sixty articles were initially identified. Following removal of duplicates and application of inclusion/exclusion criteria, 312 articles were included for qualitative analysis.Results: The 312 articles encompassed a total of 507 patients with most lesions located within the mandible (74.3%). The most common first histological diagnosis was ameloblastic carcinoma (25.7% of all diagnoses), but there is considerable variation in how and when various diagnostic terms are used, and several misdiagnoses were reported. An initial benign diagnosis was made in 24.7% of patients, followed by a later malignant diagnosis and in this sub-group, the most common benign first diagnosis was ameloblastoma (42.4%). Cervical lymph nodes were the most common site of metastasis (9.3% of patients). With respect to distant metastasis (DM), the lungs were the most common organ affected (11.2% of DM patients) with metastasising ameloblastoma the most commonly reported tumour which metastasised to the lungs. Overall, 26.8% of patients developed recurrence.Conclusion: Overall, the quality of the literature on MOTs is poor. This review of the literature has highlighted variations in diagnostic terms and criteria which has resulted in areas of confusion with potential for misdiagnosis. This consolidation of primary data has identified key areas for targeted research including further discussion on the malignant potential of ameloblastoma.Constanza MarinConstanza MarinManas DaveKeith D. HunterKeith D. HunterFrontiers Media S.A.articleodontogenic tumourmalignant odontogenic tumourradiographic featurestreatmentrecurrenceDentistryRK1-715ENFrontiers in Oral Health, Vol 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	odontogenic tumour malignant odontogenic tumour radiographic features treatment recurrence Dentistry RK1-715
spellingShingle	odontogenic tumour malignant odontogenic tumour radiographic features treatment recurrence Dentistry RK1-715 Constanza Marin Constanza Marin Manas Dave Keith D. Hunter Keith D. Hunter Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature
description	Background: Malignant odontogenic tumours (MOTs) arise either de novo from the tooth forming tissues, their developmental residues or from existing odontogenic epithelial or mesenchymal neoplasms in the jaws. Their management requires extensive surgery due to their infiltrative nature and risk of metastasis. There is a need to understand the clinical and pathological features of MOTs to inform both treatment algorithms and prognostication. This is an area of diagnostic pathology which presents substantial difficulties in diagnosis, compounded by inconsistent use of terminology. Thus, this systematic review aimed to describe the clinical and pathological features of MOTs with a view to consolidating the literature and defining problematic areas in diagnosis and classification.Methods: An electronic database search was conducted in Web of Science, PubMed/Medline, and Embase. Additionally, the grey literature and reference lists of selected papers searched for completeness. Nine hundred and sixty articles were initially identified. Following removal of duplicates and application of inclusion/exclusion criteria, 312 articles were included for qualitative analysis.Results: The 312 articles encompassed a total of 507 patients with most lesions located within the mandible (74.3%). The most common first histological diagnosis was ameloblastic carcinoma (25.7% of all diagnoses), but there is considerable variation in how and when various diagnostic terms are used, and several misdiagnoses were reported. An initial benign diagnosis was made in 24.7% of patients, followed by a later malignant diagnosis and in this sub-group, the most common benign first diagnosis was ameloblastoma (42.4%). Cervical lymph nodes were the most common site of metastasis (9.3% of patients). With respect to distant metastasis (DM), the lungs were the most common organ affected (11.2% of DM patients) with metastasising ameloblastoma the most commonly reported tumour which metastasised to the lungs. Overall, 26.8% of patients developed recurrence.Conclusion: Overall, the quality of the literature on MOTs is poor. This review of the literature has highlighted variations in diagnostic terms and criteria which has resulted in areas of confusion with potential for misdiagnosis. This consolidation of primary data has identified key areas for targeted research including further discussion on the malignant potential of ameloblastoma.
format	article
author	Constanza Marin Constanza Marin Manas Dave Keith D. Hunter Keith D. Hunter
author_facet	Constanza Marin Constanza Marin Manas Dave Keith D. Hunter Keith D. Hunter
author_sort	Constanza Marin
title	Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature
title_short	Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature
title_full	Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature
title_fullStr	Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature
title_full_unstemmed	Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature
title_sort	malignant odontogenic tumours: a systematic review of cases reported in literature
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cf68e2b02d49458d829f34b33582bd58
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Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

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