Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention
Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbri...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:cf68eac64834418ba36d09e57c0c62182021-11-30T17:23:27ZMicroglia in Alzheimer’s Disease: A Target for Therapeutic Intervention1662-510210.3389/fncel.2021.749587https://doaj.org/article/cf68eac64834418ba36d09e57c0c62182021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.749587/fullhttps://doaj.org/toc/1662-5102Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.Guimei ZhangZicheng WangHuiling HuMeng ZhaoLi SunFrontiers Media S.A.articleAlzheimer’s diseaseβ-amyloidmicroglianeuroinflammationtauNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Alzheimer’s disease β-amyloid microglia neuroinflammation tau Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
Alzheimer’s disease β-amyloid microglia neuroinflammation tau Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Guimei Zhang Zicheng Wang Huiling Hu Meng Zhao Li Sun Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention |
| description |
Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs. |
| format |
article |
| author |
Guimei Zhang Zicheng Wang Huiling Hu Meng Zhao Li Sun |
| author_facet |
Guimei Zhang Zicheng Wang Huiling Hu Meng Zhao Li Sun |
| author_sort |
Guimei Zhang |
| title |
Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention |
| title_short |
Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention |
| title_full |
Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention |
| title_fullStr |
Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention |
| title_full_unstemmed |
Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention |
| title_sort |
microglia in alzheimer’s disease: a target for therapeutic intervention |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/cf68eac64834418ba36d09e57c0c6218 |
| work_keys_str_mv |
AT guimeizhang microgliainalzheimersdiseaseatargetfortherapeuticintervention AT zichengwang microgliainalzheimersdiseaseatargetfortherapeuticintervention AT huilinghu microgliainalzheimersdiseaseatargetfortherapeuticintervention AT mengzhao microgliainalzheimersdiseaseatargetfortherapeuticintervention AT lisun microgliainalzheimersdiseaseatargetfortherapeuticintervention |
| _version_ |
1718406410087170048 |