Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan

Abstract We investigated the relationship of different primary subsites together with their pathological features on the survival of oral cavity squamous cell carcinoma (OCSCC) patients. We retrospectively reviewed OCSCC patients and documented their demographic data, pathological features and clini...

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Autores principales:	Shih-An Liu, Chen-Chi Wang, Rong-San Jiang, Fang-Yi Lee, Wen-Jiun Lin, Jin-Ching Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf699aae5beb4711bdd96802f021f963
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spelling	oai:doaj.org-article:cf699aae5beb4711bdd96802f021f9632021-12-02T15:06:20ZPathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan10.1038/s41598-017-08022-w2045-2322https://doaj.org/article/cf699aae5beb4711bdd96802f021f9632017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08022-whttps://doaj.org/toc/2045-2322Abstract We investigated the relationship of different primary subsites together with their pathological features on the survival of oral cavity squamous cell carcinoma (OCSCC) patients. We retrospectively reviewed OCSCC patients and documented their demographic data, pathological features and clinical outcome. The Cox proportional hazard model was used to examine the influence of various pathological features on the prognosis in different subsites of oral cavity. There were totally 1,383 OCSCC patients enrolled for final analysis. Perineural invasion had a poor prognosis at the early stage of OCSCC patients especially those with primary at the tongue. In addition, lymphovascular invasion was associated with poor survival at the late stage especially those with primary at the buccal mucosa and the tongue. The impact of pathological features on the survival of OCSCC patients varied in different subsites. Further investigation is warranted to validate our finding in a multicenter study. Grouping the different markers to establish a prognostic scoring system may provide more accurate evaluation of the prognosis in OCSCC patients.Shih-An LiuChen-Chi WangRong-San JiangFang-Yi LeeWen-Jiun LinJin-Ching LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shih-An Liu Chen-Chi Wang Rong-San Jiang Fang-Yi Lee Wen-Jiun Lin Jin-Ching Lin Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
description	Abstract We investigated the relationship of different primary subsites together with their pathological features on the survival of oral cavity squamous cell carcinoma (OCSCC) patients. We retrospectively reviewed OCSCC patients and documented their demographic data, pathological features and clinical outcome. The Cox proportional hazard model was used to examine the influence of various pathological features on the prognosis in different subsites of oral cavity. There were totally 1,383 OCSCC patients enrolled for final analysis. Perineural invasion had a poor prognosis at the early stage of OCSCC patients especially those with primary at the tongue. In addition, lymphovascular invasion was associated with poor survival at the late stage especially those with primary at the buccal mucosa and the tongue. The impact of pathological features on the survival of OCSCC patients varied in different subsites. Further investigation is warranted to validate our finding in a multicenter study. Grouping the different markers to establish a prognostic scoring system may provide more accurate evaluation of the prognosis in OCSCC patients.
format	article
author	Shih-An Liu Chen-Chi Wang Rong-San Jiang Fang-Yi Lee Wen-Jiun Lin Jin-Ching Lin
author_facet	Shih-An Liu Chen-Chi Wang Rong-San Jiang Fang-Yi Lee Wen-Jiun Lin Jin-Ching Lin
author_sort	Shih-An Liu
title	Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
title_short	Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
title_full	Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
title_fullStr	Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
title_full_unstemmed	Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan
title_sort	pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – a singe institute’s experience in taiwan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cf699aae5beb4711bdd96802f021f963
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Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan

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