Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.

Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in de...

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Autores principales:	Jaqueline Goes de Jesus, Tiago Gräf, Marta Giovanetti, Maria Angélica Mares-Guia, Joilson Xavier, Maricelia Lima Maia, Vagner Fonseca, Allison Fabri, Roberto Fonseca Dos Santos, Felicidade Mota Pereira, Leandro Ferraz Oliveira Santos, Luciana Reboredo de Oliveira da Silva, Zuinara Pereira Gusmão Maia, Jananci Xavier Gomes Cerqueira, Julien Thèze, Leandro Abade, Mirza de Carvalho Santana Cordeiro, Sintia Sacramento Cerqueira Torquato, Eloisa Bahia Santana, Neuza Santos de Jesus Silva, Rosemary Sarmento Oitiçica Dourado, Ademilson Brás Alves, Adeilde do Socorro Guedes, Pedro Macedo da Silva Filho, Nuno Rodrigues Faria, Carlos F Campelo de Albuquerque, André Luiz de Abreu, Alessandro Pecego Martins Romano, Julio Croda, Rodrigo Fabiano do Carmo Said, Gabriel Muricy Cunha, Jeane Magnavita da Fonseca Cerqueira, Arabela Leal E Silva de Mello, Ana Maria Bispo de Filippis, Luiz Carlos Junior Alcantara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/cf6ac88a49214786994f6336399d3d7f
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spelling	oai:doaj.org-article:cf6ac88a49214786994f6336399d3d7f2021-12-02T20:23:49ZYellow fever transmission in non-human primates, Bahia, Northeastern Brazil.1935-27271935-273510.1371/journal.pntd.0008405https://doaj.org/article/cf6ac88a49214786994f6336399d3d7f2020-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0008405https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP. Among affected areas, Bahia state in Northeastern was the only region with no autochthonous human cases. By using next generation sequence approach, we investigated the molecular epidemiology of YFV in NHP in Bahia and discuss what factors might have prevented human cases. We investigated 47 YFV positive tissue samples from NHP cases to generate 8 novel YFV genomes. ML phylogenetic tree reconstructions and automated subtyping tools placed the newly generated genomes within the South American genotype I (SA I). Our analysis revealed that the YFV genomes from Bahia formed two distinct well-supported phylogenetic clusters that emerged most likely of an introduction from Minas Gerais and Espírito Santo states. Vegetation coverage analysis performed shows predominantly low to medium vegetation coverage in Bahia state. Together, our findings support the hypothesis of two independent YFV SA-I introductions. We also highlighted the effectiveness of the actions taken by epidemiological surveillance team of the state to prevented human cases.Jaqueline Goes de JesusTiago GräfMarta GiovanettiMaria Angélica Mares-GuiaJoilson XavierMaricelia Lima MaiaVagner FonsecaAllison FabriRoberto Fonseca Dos SantosFelicidade Mota PereiraLeandro Ferraz Oliveira SantosLuciana Reboredo de Oliveira da SilvaZuinara Pereira Gusmão MaiaJananci Xavier Gomes CerqueiraJulien ThèzeLeandro AbadeMirza de Carvalho Santana CordeiroSintia Sacramento Cerqueira TorquatoEloisa Bahia SantanaNeuza Santos de Jesus SilvaRosemary Sarmento Oitiçica DouradoAdemilson Brás AlvesAdeilde do Socorro GuedesPedro Macedo da Silva FilhoNuno Rodrigues FariaCarlos F Campelo de AlbuquerqueAndré Luiz de AbreuAlessandro Pecego Martins RomanoJulio CrodaRodrigo Fabiano do Carmo SaidGabriel Muricy CunhaJeane Magnavita da Fonseca CerqueiraArabela Leal E Silva de MelloAna Maria Bispo de FilippisLuiz Carlos Junior AlcantaraPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008405 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jaqueline Goes de Jesus Tiago Gräf Marta Giovanetti Maria Angélica Mares-Guia Joilson Xavier Maricelia Lima Maia Vagner Fonseca Allison Fabri Roberto Fonseca Dos Santos Felicidade Mota Pereira Leandro Ferraz Oliveira Santos Luciana Reboredo de Oliveira da Silva Zuinara Pereira Gusmão Maia Jananci Xavier Gomes Cerqueira Julien Thèze Leandro Abade Mirza de Carvalho Santana Cordeiro Sintia Sacramento Cerqueira Torquato Eloisa Bahia Santana Neuza Santos de Jesus Silva Rosemary Sarmento Oitiçica Dourado Ademilson Brás Alves Adeilde do Socorro Guedes Pedro Macedo da Silva Filho Nuno Rodrigues Faria Carlos F Campelo de Albuquerque André Luiz de Abreu Alessandro Pecego Martins Romano Julio Croda Rodrigo Fabiano do Carmo Said Gabriel Muricy Cunha Jeane Magnavita da Fonseca Cerqueira Arabela Leal E Silva de Mello Ana Maria Bispo de Filippis Luiz Carlos Junior Alcantara Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
description	Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP. Among affected areas, Bahia state in Northeastern was the only region with no autochthonous human cases. By using next generation sequence approach, we investigated the molecular epidemiology of YFV in NHP in Bahia and discuss what factors might have prevented human cases. We investigated 47 YFV positive tissue samples from NHP cases to generate 8 novel YFV genomes. ML phylogenetic tree reconstructions and automated subtyping tools placed the newly generated genomes within the South American genotype I (SA I). Our analysis revealed that the YFV genomes from Bahia formed two distinct well-supported phylogenetic clusters that emerged most likely of an introduction from Minas Gerais and Espírito Santo states. Vegetation coverage analysis performed shows predominantly low to medium vegetation coverage in Bahia state. Together, our findings support the hypothesis of two independent YFV SA-I introductions. We also highlighted the effectiveness of the actions taken by epidemiological surveillance team of the state to prevented human cases.
format	article
author	Jaqueline Goes de Jesus Tiago Gräf Marta Giovanetti Maria Angélica Mares-Guia Joilson Xavier Maricelia Lima Maia Vagner Fonseca Allison Fabri Roberto Fonseca Dos Santos Felicidade Mota Pereira Leandro Ferraz Oliveira Santos Luciana Reboredo de Oliveira da Silva Zuinara Pereira Gusmão Maia Jananci Xavier Gomes Cerqueira Julien Thèze Leandro Abade Mirza de Carvalho Santana Cordeiro Sintia Sacramento Cerqueira Torquato Eloisa Bahia Santana Neuza Santos de Jesus Silva Rosemary Sarmento Oitiçica Dourado Ademilson Brás Alves Adeilde do Socorro Guedes Pedro Macedo da Silva Filho Nuno Rodrigues Faria Carlos F Campelo de Albuquerque André Luiz de Abreu Alessandro Pecego Martins Romano Julio Croda Rodrigo Fabiano do Carmo Said Gabriel Muricy Cunha Jeane Magnavita da Fonseca Cerqueira Arabela Leal E Silva de Mello Ana Maria Bispo de Filippis Luiz Carlos Junior Alcantara
author_facet	Jaqueline Goes de Jesus Tiago Gräf Marta Giovanetti Maria Angélica Mares-Guia Joilson Xavier Maricelia Lima Maia Vagner Fonseca Allison Fabri Roberto Fonseca Dos Santos Felicidade Mota Pereira Leandro Ferraz Oliveira Santos Luciana Reboredo de Oliveira da Silva Zuinara Pereira Gusmão Maia Jananci Xavier Gomes Cerqueira Julien Thèze Leandro Abade Mirza de Carvalho Santana Cordeiro Sintia Sacramento Cerqueira Torquato Eloisa Bahia Santana Neuza Santos de Jesus Silva Rosemary Sarmento Oitiçica Dourado Ademilson Brás Alves Adeilde do Socorro Guedes Pedro Macedo da Silva Filho Nuno Rodrigues Faria Carlos F Campelo de Albuquerque André Luiz de Abreu Alessandro Pecego Martins Romano Julio Croda Rodrigo Fabiano do Carmo Said Gabriel Muricy Cunha Jeane Magnavita da Fonseca Cerqueira Arabela Leal E Silva de Mello Ana Maria Bispo de Filippis Luiz Carlos Junior Alcantara
author_sort	Jaqueline Goes de Jesus
title	Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
title_short	Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
title_full	Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
title_fullStr	Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
title_full_unstemmed	Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
title_sort	yellow fever transmission in non-human primates, bahia, northeastern brazil.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/cf6ac88a49214786994f6336399d3d7f
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Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil.

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