Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.

<h4>Background</h4>The lung clearance index (LCI), measured by multiple breath washout (MBW), reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis (CF) lung disease. Current evidence is based on a customized mass spectrometry system that uses sulfu...

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Autores principales:	Renee Jensen, Sanja Stanojevic, Karyn Gibney, Juliana Giraldo Salazar, Per Gustafsson, Padmaja Subbarao, Felix Ratjen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf6bd245b41e49fd8a2f933ab0d17f6b
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spelling	oai:doaj.org-article:cf6bd245b41e49fd8a2f933ab0d17f6b2021-11-18T07:57:16ZMultiple breath nitrogen washout: a feasible alternative to mass spectrometry.1932-620310.1371/journal.pone.0056868https://doaj.org/article/cf6bd245b41e49fd8a2f933ab0d17f6b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23457632/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The lung clearance index (LCI), measured by multiple breath washout (MBW), reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis (CF) lung disease. Current evidence is based on a customized mass spectrometry system that uses sulfur hexafluoride (SF6) as a tracer gas, which is not widely available. Nitrogen (N2) washout may be better suited for clinical use and multi-center trials.<h4>Objective</h4>To compare the results obtained from a N2 washout system to those generated by the SF6 based system in healthy children and children with CF.<h4>Methods</h4>Children with CF were recruited from outpatient clinics; healthy children were recruited from the Research4Kids online portal. Participants performed MBWSF6 (Amis 2000, Innovision, Denmark) and MBWN2 (ExhalyzerD, EcoMedics, Switzerland) in triplicate, in random order on the same day. Agreement between systems was assessed by Bland-Altman plot.<h4>Results</h4>Sixty-two healthy and 61 children with CF completed measurements on both systems. In health there was good agreement between systems (limits of agreement -0.7 to 1.9); on average N2 produced higher values of LCI (mean difference 0.58 (95% CI 0.42 to 0.74)). In CF the difference between systems was double that in health with a clear bias towards disproportionately higher LCIN2 compared to LCISF6 at higher mean values of LCI.<h4>Conclusion</h4>LCIN2 and LCISF6 have similar discriminative power and intra-session repeatability but are not interchangeable. MBWN2 offers a valid new tool to investigate early obstructive lung disease in CF, but requires independent normative values.Renee JensenSanja StanojevicKaryn GibneyJuliana Giraldo SalazarPer GustafssonPadmaja SubbaraoFelix RatjenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56868 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renee Jensen Sanja Stanojevic Karyn Gibney Juliana Giraldo Salazar Per Gustafsson Padmaja Subbarao Felix Ratjen Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
description	<h4>Background</h4>The lung clearance index (LCI), measured by multiple breath washout (MBW), reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis (CF) lung disease. Current evidence is based on a customized mass spectrometry system that uses sulfur hexafluoride (SF6) as a tracer gas, which is not widely available. Nitrogen (N2) washout may be better suited for clinical use and multi-center trials.<h4>Objective</h4>To compare the results obtained from a N2 washout system to those generated by the SF6 based system in healthy children and children with CF.<h4>Methods</h4>Children with CF were recruited from outpatient clinics; healthy children were recruited from the Research4Kids online portal. Participants performed MBWSF6 (Amis 2000, Innovision, Denmark) and MBWN2 (ExhalyzerD, EcoMedics, Switzerland) in triplicate, in random order on the same day. Agreement between systems was assessed by Bland-Altman plot.<h4>Results</h4>Sixty-two healthy and 61 children with CF completed measurements on both systems. In health there was good agreement between systems (limits of agreement -0.7 to 1.9); on average N2 produced higher values of LCI (mean difference 0.58 (95% CI 0.42 to 0.74)). In CF the difference between systems was double that in health with a clear bias towards disproportionately higher LCIN2 compared to LCISF6 at higher mean values of LCI.<h4>Conclusion</h4>LCIN2 and LCISF6 have similar discriminative power and intra-session repeatability but are not interchangeable. MBWN2 offers a valid new tool to investigate early obstructive lung disease in CF, but requires independent normative values.
format	article
author	Renee Jensen Sanja Stanojevic Karyn Gibney Juliana Giraldo Salazar Per Gustafsson Padmaja Subbarao Felix Ratjen
author_facet	Renee Jensen Sanja Stanojevic Karyn Gibney Juliana Giraldo Salazar Per Gustafsson Padmaja Subbarao Felix Ratjen
author_sort	Renee Jensen
title	Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
title_short	Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
title_full	Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
title_fullStr	Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
title_full_unstemmed	Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
title_sort	multiple breath nitrogen washout: a feasible alternative to mass spectrometry.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cf6bd245b41e49fd8a2f933ab0d17f6b
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_version_	1718422758015107072

Multiple breath nitrogen washout: a feasible alternative to mass spectrometry.

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