Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar

Background: Tuberculosis (TB) is among the top 10 causes of death worldwide and there are estimated 10.4 million new (incident) patients, of which about one fourth are in India. There has been calls for rigorous investigations and interventions that may address other factors known to have effect on...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abdul Rouf, Muneer A Masoodi, Mohammad Maqbool Dar, S. Mohammad Salim Khan, Rubeena Bilquise
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Depression Tuberculosis Prevalence Incidence Treatment outcomes Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/cf6c5bbdb031451790df6a126bb6e014
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf6c5bbdb031451790df6a126bb6e014
record_format	dspace
spelling	oai:doaj.org-article:cf6c5bbdb031451790df6a126bb6e0142021-11-30T04:16:28ZDepression among Tuberculosis patients and its association with treatment outcomes in district Srinagar2405-579410.1016/j.jctube.2021.100281https://doaj.org/article/cf6c5bbdb031451790df6a126bb6e0142021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S240557942100070Xhttps://doaj.org/toc/2405-5794Background: Tuberculosis (TB) is among the top 10 causes of death worldwide and there are estimated 10.4 million new (incident) patients, of which about one fourth are in India. There has been calls for rigorous investigations and interventions that may address other factors known to have effect on adherence of treatment like Depression but the amount of research into comorbidity is surprisingly low. The aim of the study was to assess magnitude and impact of depression among TB patients and determine the treatment outcomes of TB in District Srinagar. Methods: In this prospective study the adults with newly diagnosed TB were recruited within one month of initiating treatment and were followed upto the end of treatment. Data collection was done at three time-points: baseline, after 2 months and after 6 months of treatment initiation. The sample size of 200 was calculated using OpenEpi, V3 and identified 202 TB patients were interviewed in their local language and PHQ-9 scale was used to measure Depression. Results: The prevalence of Depression at baseline was 50.5% with CI (43.7%-57.3%). After two months of treatment the prevalence reduced to 9.4% with CI (5.9%-14.0%) and at the end of treatment to 2.5% with CI (0.91%-5.4%). Association between Depression in TB patients and treatment failure was found to be small to medium as revealed by Cramer’s V test (0.29–0.59). Binary logistic regression estimated that at baseline TB patients with Depression were at 4.46 times at more risk of treatment failure than patients without Depression and those patients who continued Depression even after intensive phase were 34.5 times at higher risk. Conclusion: Our findings indicate Depression is associated with poor treatment outcome in these patients, despite TB treatment. TB treatment strategies should consider screening and managing the psychologically distressed individuals among TB patients.Abdul RoufMuneer A MasoodiMohammad Maqbool DarS. Mohammad Salim KhanRubeena BilquiseElsevierarticleDepressionTuberculosisPrevalenceIncidenceTreatment outcomesDiseases of the respiratory systemRC705-779Infectious and parasitic diseasesRC109-216ENJournal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 25, Iss , Pp 100281- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression Tuberculosis Prevalence Incidence Treatment outcomes Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
spellingShingle	Depression Tuberculosis Prevalence Incidence Treatment outcomes Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216 Abdul Rouf Muneer A Masoodi Mohammad Maqbool Dar S. Mohammad Salim Khan Rubeena Bilquise Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar
description	Background: Tuberculosis (TB) is among the top 10 causes of death worldwide and there are estimated 10.4 million new (incident) patients, of which about one fourth are in India. There has been calls for rigorous investigations and interventions that may address other factors known to have effect on adherence of treatment like Depression but the amount of research into comorbidity is surprisingly low. The aim of the study was to assess magnitude and impact of depression among TB patients and determine the treatment outcomes of TB in District Srinagar. Methods: In this prospective study the adults with newly diagnosed TB were recruited within one month of initiating treatment and were followed upto the end of treatment. Data collection was done at three time-points: baseline, after 2 months and after 6 months of treatment initiation. The sample size of 200 was calculated using OpenEpi, V3 and identified 202 TB patients were interviewed in their local language and PHQ-9 scale was used to measure Depression. Results: The prevalence of Depression at baseline was 50.5% with CI (43.7%-57.3%). After two months of treatment the prevalence reduced to 9.4% with CI (5.9%-14.0%) and at the end of treatment to 2.5% with CI (0.91%-5.4%). Association between Depression in TB patients and treatment failure was found to be small to medium as revealed by Cramer’s V test (0.29–0.59). Binary logistic regression estimated that at baseline TB patients with Depression were at 4.46 times at more risk of treatment failure than patients without Depression and those patients who continued Depression even after intensive phase were 34.5 times at higher risk. Conclusion: Our findings indicate Depression is associated with poor treatment outcome in these patients, despite TB treatment. TB treatment strategies should consider screening and managing the psychologically distressed individuals among TB patients.
format	article
author	Abdul Rouf Muneer A Masoodi Mohammad Maqbool Dar S. Mohammad Salim Khan Rubeena Bilquise
author_facet	Abdul Rouf Muneer A Masoodi Mohammad Maqbool Dar S. Mohammad Salim Khan Rubeena Bilquise
author_sort	Abdul Rouf
title	Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar
title_short	Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar
title_full	Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar
title_fullStr	Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar
title_full_unstemmed	Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar
title_sort	depression among tuberculosis patients and its association with treatment outcomes in district srinagar
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cf6c5bbdb031451790df6a126bb6e014
work_keys_str_mv	AT abdulrouf depressionamongtuberculosispatientsanditsassociationwithtreatmentoutcomesindistrictsrinagar AT muneeramasoodi depressionamongtuberculosispatientsanditsassociationwithtreatmentoutcomesindistrictsrinagar AT mohammadmaqbooldar depressionamongtuberculosispatientsanditsassociationwithtreatmentoutcomesindistrictsrinagar AT smohammadsalimkhan depressionamongtuberculosispatientsanditsassociationwithtreatmentoutcomesindistrictsrinagar AT rubeenabilquise depressionamongtuberculosispatientsanditsassociationwithtreatmentoutcomesindistrictsrinagar
_version_	1718406831369355264

Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar

Ejemplares similares