Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

Abstract Background The COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, change...

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Autores principales:	Hamid Reza Kouhpayeh, Farhad Tabasi, Mohammad Dehvari, Mohammad Naderi, Gholamreza Bahari, Tahereh Khalili, Courtney Clark, Saeid Ghavami, Mohsen Taheri
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 SARS-CoV-2 Angiotensin AGT ACE AGTR1 Medicine R
Acceso en línea:	https://doaj.org/article/cf6c7b2818d3468eb599f3771376cc60
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spelling	oai:doaj.org-article:cf6c7b2818d3468eb599f3771376cc602021-11-21T12:42:32ZAssociation between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study10.1186/s41231-021-00106-02396-832Xhttps://doaj.org/article/cf6c7b2818d3468eb599f3771376cc602021-11-01T00:00:00Zhttps://doi.org/10.1186/s41231-021-00106-0https://doaj.org/toc/2396-832XAbstract Background The COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, changes in the renin-angiotensin system (RAS) balance alter an individual’s susceptibility to COVID-19 infection. We aimed to evaluate the association between AGT rs699 C > T, ACE rs4646994 I/D, and AGTR1 rs5186 C > A variants and the risk of COVID-19 infection and the severity in a sample of the southeast Iranian population. Methods A total of 504 subjects, including 258 COVID-19 positives, and 246 healthy controls, were recruited. Genotyping of the ACE gene rs4646994, and AGT rs699, and AGTR1 rs5186 polymorphisms was performed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP), respectively. Results Our results showed that the II genotype of ACE rs4646994 and the I allele decreased the risk of COVID-19 infection. Moreover, we found that the TC genotype and C allele of AGT rs699 increased the risk of COVID-19 infection. The AGTR1 rs5186 was not associated with COVID-19 infection. Also, we did not find any association between these polymorphisms and the severity of the disease. However, we found a significantly higher age and prevalence of diabetes and hypertension in patients with severe disease than a non-severe disease. Conclusions These findings suggest that ACE rs4646994 and AGT rs699 polymorphisms increase the risk of COVID-19 infection in a southeast Iranian population.Hamid Reza KouhpayehFarhad TabasiMohammad DehvariMohammad NaderiGholamreza BahariTahereh KhaliliCourtney ClarkSaeid GhavamiMohsen TaheriBMCarticleCOVID-19SARS-CoV-2AngiotensinAGTACEAGTR1MedicineRENTranslational Medicine Communications, Vol 6, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 Angiotensin AGT ACE AGTR1 Medicine R
spellingShingle	COVID-19 SARS-CoV-2 Angiotensin AGT ACE AGTR1 Medicine R Hamid Reza Kouhpayeh Farhad Tabasi Mohammad Dehvari Mohammad Naderi Gholamreza Bahari Tahereh Khalili Courtney Clark Saeid Ghavami Mohsen Taheri Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
description	Abstract Background The COVID-19 pandemic remains an emerging public health crisis with serious adverse effects. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV--2) infection, targeting angiotensin-converting enzyme-2 (ACE2) receptor for cell entry. However, changes in the renin-angiotensin system (RAS) balance alter an individual’s susceptibility to COVID-19 infection. We aimed to evaluate the association between AGT rs699 C > T, ACE rs4646994 I/D, and AGTR1 rs5186 C > A variants and the risk of COVID-19 infection and the severity in a sample of the southeast Iranian population. Methods A total of 504 subjects, including 258 COVID-19 positives, and 246 healthy controls, were recruited. Genotyping of the ACE gene rs4646994, and AGT rs699, and AGTR1 rs5186 polymorphisms was performed by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP), respectively. Results Our results showed that the II genotype of ACE rs4646994 and the I allele decreased the risk of COVID-19 infection. Moreover, we found that the TC genotype and C allele of AGT rs699 increased the risk of COVID-19 infection. The AGTR1 rs5186 was not associated with COVID-19 infection. Also, we did not find any association between these polymorphisms and the severity of the disease. However, we found a significantly higher age and prevalence of diabetes and hypertension in patients with severe disease than a non-severe disease. Conclusions These findings suggest that ACE rs4646994 and AGT rs699 polymorphisms increase the risk of COVID-19 infection in a southeast Iranian population.
format	article
author	Hamid Reza Kouhpayeh Farhad Tabasi Mohammad Dehvari Mohammad Naderi Gholamreza Bahari Tahereh Khalili Courtney Clark Saeid Ghavami Mohsen Taheri
author_facet	Hamid Reza Kouhpayeh Farhad Tabasi Mohammad Dehvari Mohammad Naderi Gholamreza Bahari Tahereh Khalili Courtney Clark Saeid Ghavami Mohsen Taheri
author_sort	Hamid Reza Kouhpayeh
title	Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
title_short	Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
title_full	Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
title_fullStr	Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
title_full_unstemmed	Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
title_sort	association between angiotensinogen (agt), angiotensin-converting enzyme (ace) and angiotensin-ii receptor 1 (agtr1) polymorphisms and covid-19 infection in the southeast of iran: a preliminary case-control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cf6c7b2818d3468eb599f3771376cc60
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Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

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