Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release

Eloísa Berbel Manaia,1 Renata Cristina Kiatkoski Kaminski,2 Anselmo Gomes de Oliveira,1 Marcos Antonio Corrêa,1 Leila Aparecida Chiavacci1 1Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, 2Physical-Chemistry Department, Chemistry Institute, São P...

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Autores principales:	Manaia EB, Kaminski RCK, Oliveira AG, Corrêa MA, Chiavacci LA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cf6d79d499114f6b9bbd725b09344e76
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spelling	oai:doaj.org-article:cf6d79d499114f6b9bbd725b09344e762021-12-02T07:15:35ZMultifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release1178-2013https://doaj.org/article/cf6d79d499114f6b9bbd725b09344e762015-01-01T00:00:00Zhttp://www.dovepress.com/multifunction-hexagonal-liquid-crystal-containing-modified-surface-tio-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Eloísa Berbel Manaia,1 Renata Cristina Kiatkoski Kaminski,2 Anselmo Gomes de Oliveira,1 Marcos Antonio Corrêa,1 Leila Aparecida Chiavacci1 1Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, 2Physical-Chemistry Department, Chemistry Institute, São Paulo State University – UNESP, Araraquara, Brazil Abstract: Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO2) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO2 nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO2 nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO2 nanoparticles can act as a transparent inorganic sunscreen. Keywords: titanium dioxide, sol-gel, drug delivery, sunscreenManaia EBKaminski RCKOliveira AGCorrêa MAChiavacci LADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 811-819 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Manaia EB Kaminski RCK Oliveira AG Corrêa MA Chiavacci LA Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release
description	Eloísa Berbel Manaia,1 Renata Cristina Kiatkoski Kaminski,2 Anselmo Gomes de Oliveira,1 Marcos Antonio Corrêa,1 Leila Aparecida Chiavacci1 1Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, 2Physical-Chemistry Department, Chemistry Institute, São Paulo State University – UNESP, Araraquara, Brazil Abstract: Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO2) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO2 nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO2 nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO2 nanoparticles can act as a transparent inorganic sunscreen. Keywords: titanium dioxide, sol-gel, drug delivery, sunscreen
format	article
author	Manaia EB Kaminski RCK Oliveira AG Corrêa MA Chiavacci LA
author_facet	Manaia EB Kaminski RCK Oliveira AG Corrêa MA Chiavacci LA
author_sort	Manaia EB
title	Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release
title_short	Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release
title_full	Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release
title_fullStr	Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release
title_full_unstemmed	Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release
title_sort	multifunction hexagonal liquid-crystal containing modified surface tio2 nanoparticles and terpinen-4-ol for controlled release
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/cf6d79d499114f6b9bbd725b09344e76
work_keys_str_mv	AT manaiaeb multifunctionhexagonalliquidcrystalcontainingmodifiedsurfacetio2nanoparticlesandterpinen4olforcontrolledrelease AT kaminskirck multifunctionhexagonalliquidcrystalcontainingmodifiedsurfacetio2nanoparticlesandterpinen4olforcontrolledrelease AT oliveiraag multifunctionhexagonalliquidcrystalcontainingmodifiedsurfacetio2nanoparticlesandterpinen4olforcontrolledrelease AT correama multifunctionhexagonalliquidcrystalcontainingmodifiedsurfacetio2nanoparticlesandterpinen4olforcontrolledrelease AT chiavaccila multifunctionhexagonalliquidcrystalcontainingmodifiedsurfacetio2nanoparticlesandterpinen4olforcontrolledrelease
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Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release

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