Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease

Background: Cognitive deficits are prominent non-motor symptoms in Parkinson’s disease (PD) and have been shown to involve the neurovascular unit (NVU). However, there is a lack of sufficient neuroimaging research on the associated modulating mechanisms. The objective of this study was to identify t...

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Autores principales:	Song’an Shang, Hongying Zhang, Yuan Feng, Jingtao Wu, Weiqiang Dou, Yu-Chen Chen, Xindao Yin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease neurovascular coupling cognitive impairment magnetic resonance imaging regional homogeneity cerebral blood flow Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/cf6e94d0c756435c85a57873559a051b
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spelling	oai:doaj.org-article:cf6e94d0c756435c85a57873559a051b2021-11-15T06:59:47ZRegion-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease1663-436510.3389/fnagi.2021.770528https://doaj.org/article/cf6e94d0c756435c85a57873559a051b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.770528/fullhttps://doaj.org/toc/1663-4365Background: Cognitive deficits are prominent non-motor symptoms in Parkinson’s disease (PD) and have been shown to involve the neurovascular unit (NVU). However, there is a lack of sufficient neuroimaging research on the associated modulating mechanisms. The objective of this study was to identify the contribution of neurovascular decoupling to the pathogenesis of cognitive decline in PD.Methods: Regional homogeneity (ReHo), a measure of neuronal activity, and cerebral blood flow (CBF), a measure of vascular responses, were obtained from patients with PD with mild cognitive impairment (MCI) and normal cognition (NC) as well as matched healthy controls (HCs). Imaging metrics of neurovascular coupling (global and regional CBF-ReHo correlation coefficients and CBF-ReHo ratios) were compared among the groups.Results: Neurovascular coupling was impaired in patients with PD-MCI with a decreased global CBF-ReHo correlation coefficient relative to HC subjects (P < 0.05). Regional dysregulation was specific to the PD-MCI group and localized to the right middle frontal gyrus, right middle cingulate cortex, right middle occipital gyrus, right inferior parietal gyrus, right supramarginal gyrus, and right angular gyrus (P < 0.05). Compared with HC subjects, patients with PD-MCI showed higher CBF-ReHo ratios in the bilateral lingual gyri (LG), bilateral putamen, and left postcentral gyrus and lower CBF-ReHo ratios in the right superior temporal gyrus, bilateral middle temporal gyri, bilateral parahippocampal gyri, and right inferior frontal gyrus. Relative to the HC and PD-NC groups, the PD-MCI group showed an increased CBF-ReHo ratio in the left LG, which was correlated with poor visual–spatial performance (r = −0.36 and P = 0.014).Conclusion: The involvement of neurovascular decoupling in cognitive impairment in PD is regionally specific and most prominent in the visual–spatial cortices, which could potentially provide a complementary understanding of the pathophysiological mechanisms underlying cognitive deficits in PD.Song’an ShangHongying ZhangYuan FengJingtao WuWeiqiang DouYu-Chen ChenXindao YinFrontiers Media S.A.articleParkinson’s diseaseneurovascular couplingcognitive impairmentmagnetic resonance imagingregional homogeneitycerebral blood flowNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease neurovascular coupling cognitive impairment magnetic resonance imaging regional homogeneity cerebral blood flow Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson’s disease neurovascular coupling cognitive impairment magnetic resonance imaging regional homogeneity cerebral blood flow Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Song’an Shang Hongying Zhang Yuan Feng Jingtao Wu Weiqiang Dou Yu-Chen Chen Xindao Yin Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease
description	Background: Cognitive deficits are prominent non-motor symptoms in Parkinson’s disease (PD) and have been shown to involve the neurovascular unit (NVU). However, there is a lack of sufficient neuroimaging research on the associated modulating mechanisms. The objective of this study was to identify the contribution of neurovascular decoupling to the pathogenesis of cognitive decline in PD.Methods: Regional homogeneity (ReHo), a measure of neuronal activity, and cerebral blood flow (CBF), a measure of vascular responses, were obtained from patients with PD with mild cognitive impairment (MCI) and normal cognition (NC) as well as matched healthy controls (HCs). Imaging metrics of neurovascular coupling (global and regional CBF-ReHo correlation coefficients and CBF-ReHo ratios) were compared among the groups.Results: Neurovascular coupling was impaired in patients with PD-MCI with a decreased global CBF-ReHo correlation coefficient relative to HC subjects (P < 0.05). Regional dysregulation was specific to the PD-MCI group and localized to the right middle frontal gyrus, right middle cingulate cortex, right middle occipital gyrus, right inferior parietal gyrus, right supramarginal gyrus, and right angular gyrus (P < 0.05). Compared with HC subjects, patients with PD-MCI showed higher CBF-ReHo ratios in the bilateral lingual gyri (LG), bilateral putamen, and left postcentral gyrus and lower CBF-ReHo ratios in the right superior temporal gyrus, bilateral middle temporal gyri, bilateral parahippocampal gyri, and right inferior frontal gyrus. Relative to the HC and PD-NC groups, the PD-MCI group showed an increased CBF-ReHo ratio in the left LG, which was correlated with poor visual–spatial performance (r = −0.36 and P = 0.014).Conclusion: The involvement of neurovascular decoupling in cognitive impairment in PD is regionally specific and most prominent in the visual–spatial cortices, which could potentially provide a complementary understanding of the pathophysiological mechanisms underlying cognitive deficits in PD.
format	article
author	Song’an Shang Hongying Zhang Yuan Feng Jingtao Wu Weiqiang Dou Yu-Chen Chen Xindao Yin
author_facet	Song’an Shang Hongying Zhang Yuan Feng Jingtao Wu Weiqiang Dou Yu-Chen Chen Xindao Yin
author_sort	Song’an Shang
title	Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease
title_short	Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease
title_full	Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease
title_fullStr	Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease
title_full_unstemmed	Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease
title_sort	region-specific neurovascular decoupling associated with cognitive decline in parkinson’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cf6e94d0c756435c85a57873559a051b
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Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson’s Disease

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