Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.

<h4>Aims</h4>To determine serum zinc level and other relevant biological markers in normal, prediabetic and diabetic individuals and their association with Homeostasis Model Assessment (HOMA) parameters.<h4>Methods</h4>This cross-sectional study was conducted between March an...

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Autores principales: Md Rafiqul Islam, Iqbal Arslan, John Attia, Mark McEvoy, Patrick McElduff, Ariful Basher, Waliur Rahman, Roseanne Peel, Ayesha Akhter, Shahnaz Akter, Khanrin P Vashum, Abul Hasnat Milton
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:cf6efff0ae0e47068dc70e49a13fc7c32021-11-18T07:49:02ZIs serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.1932-620310.1371/journal.pone.0061776https://doaj.org/article/cf6efff0ae0e47068dc70e49a13fc7c32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613929/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>To determine serum zinc level and other relevant biological markers in normal, prediabetic and diabetic individuals and their association with Homeostasis Model Assessment (HOMA) parameters.<h4>Methods</h4>This cross-sectional study was conducted between March and December 2009. Any patient aged ≥ 30 years attending the medicine outpatient department of a medical university hospital in Dhaka, Bangladesh and who had a blood glucose level ordered by a physician was eligible to participate.<h4>Results</h4>A total of 280 participants were analysed. On fasting blood sugar results, 51% were normal, 13% had prediabetes and 36% had diabetes. Mean serum zinc level was lowest in prediabetic compared to normal and diabetic participants (mean differences were approximately 65 ppb/L and 33 ppb/L, respectively). In multiple linear regression, serum zinc level was found to be significantly lower in prediabetes than in those with normoglycemia. Beta cell function was significantly lower in prediabetes than normal participants. Adjusted linear regression for HOMA parameters did not show a statistically significant association between serum zinc level, beta cell function (P = 0.07) and insulin resistance (P = 0.08). Low serum zinc accentuated the increase in insulin resistance seen with increasing BMI.<h4>Conclusion</h4>Participants with prediabetes have lower zinc levels than controls and zinc is significantly associated with beta cell function and insulin resistance. Further longitudinal population based studies are warranted and controlled trials would be valuable for establishing whether zinc supplementation in prediabetes could be a useful strategy in preventing progression to Type 2 diabetes.Md Rafiqul IslamIqbal ArslanJohn AttiaMark McEvoyPatrick McElduffAriful BasherWaliur RahmanRoseanne PeelAyesha AkhterShahnaz AkterKhanrin P VashumAbul Hasnat MiltonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61776 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Md Rafiqul Islam
Iqbal Arslan
John Attia
Mark McEvoy
Patrick McElduff
Ariful Basher
Waliur Rahman
Roseanne Peel
Ayesha Akhter
Shahnaz Akter
Khanrin P Vashum
Abul Hasnat Milton
Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.
description <h4>Aims</h4>To determine serum zinc level and other relevant biological markers in normal, prediabetic and diabetic individuals and their association with Homeostasis Model Assessment (HOMA) parameters.<h4>Methods</h4>This cross-sectional study was conducted between March and December 2009. Any patient aged ≥ 30 years attending the medicine outpatient department of a medical university hospital in Dhaka, Bangladesh and who had a blood glucose level ordered by a physician was eligible to participate.<h4>Results</h4>A total of 280 participants were analysed. On fasting blood sugar results, 51% were normal, 13% had prediabetes and 36% had diabetes. Mean serum zinc level was lowest in prediabetic compared to normal and diabetic participants (mean differences were approximately 65 ppb/L and 33 ppb/L, respectively). In multiple linear regression, serum zinc level was found to be significantly lower in prediabetes than in those with normoglycemia. Beta cell function was significantly lower in prediabetes than normal participants. Adjusted linear regression for HOMA parameters did not show a statistically significant association between serum zinc level, beta cell function (P = 0.07) and insulin resistance (P = 0.08). Low serum zinc accentuated the increase in insulin resistance seen with increasing BMI.<h4>Conclusion</h4>Participants with prediabetes have lower zinc levels than controls and zinc is significantly associated with beta cell function and insulin resistance. Further longitudinal population based studies are warranted and controlled trials would be valuable for establishing whether zinc supplementation in prediabetes could be a useful strategy in preventing progression to Type 2 diabetes.
format article
author Md Rafiqul Islam
Iqbal Arslan
John Attia
Mark McEvoy
Patrick McElduff
Ariful Basher
Waliur Rahman
Roseanne Peel
Ayesha Akhter
Shahnaz Akter
Khanrin P Vashum
Abul Hasnat Milton
author_facet Md Rafiqul Islam
Iqbal Arslan
John Attia
Mark McEvoy
Patrick McElduff
Ariful Basher
Waliur Rahman
Roseanne Peel
Ayesha Akhter
Shahnaz Akter
Khanrin P Vashum
Abul Hasnat Milton
author_sort Md Rafiqul Islam
title Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.
title_short Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.
title_full Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.
title_fullStr Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.
title_full_unstemmed Is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from Bangladesh.
title_sort is serum zinc level associated with prediabetes and diabetes?: a cross-sectional study from bangladesh.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/cf6efff0ae0e47068dc70e49a13fc7c3
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