The laminar cortex model: a new continuum cortex model incorporating laminar architecture.

Local field potentials (LFPs) are widely used to study the function of local networks in the brain. They are also closely correlated with the blood-oxygen-level-dependent signal, the predominant contrast mechanism in functional magnetic resonance imaging. We developed a new laminar cortex model (LCM...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiaxin Du, Viktor Vegh, David C Reutens
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cf718ef9e623473595c014b096a95c96
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf718ef9e623473595c014b096a95c96
record_format	dspace
spelling	oai:doaj.org-article:cf718ef9e623473595c014b096a95c962021-11-18T05:52:47ZThe laminar cortex model: a new continuum cortex model incorporating laminar architecture.1553-734X1553-735810.1371/journal.pcbi.1002733https://doaj.org/article/cf718ef9e623473595c014b096a95c962012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23093925/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Local field potentials (LFPs) are widely used to study the function of local networks in the brain. They are also closely correlated with the blood-oxygen-level-dependent signal, the predominant contrast mechanism in functional magnetic resonance imaging. We developed a new laminar cortex model (LCM) to simulate the amplitude and frequency of LFPs. Our model combines the laminar architecture of the cerebral cortex and multiple continuum models to simulate the collective activity of cortical neurons. The five cortical layers (layer I, II/III, IV, V, and VI) are simulated as separate continuum models between which there are synaptic connections. The LCM was used to simulate the dynamics of the visual cortex under different conditions of visual stimulation. LFPs are reported for two kinds of visual stimulation: general visual stimulation and intermittent light stimulation. The power spectra of LFPs were calculated and compared with existing empirical data. The LCM was able to produce spontaneous LFPs exhibiting frequency-inverse (1/ƒ) power spectrum behaviour. Laminar profiles of current source density showed similarities to experimental data. General stimulation enhanced the oscillation of LFPs corresponding to gamma frequencies. During simulated intermittent light stimulation, the LCM captured the fundamental as well as high order harmonics as previously reported. The power spectrum expected with a reduction in layer IV neurons, often observed with focal cortical dysplasias associated with epilepsy was also simulated.Jiaxin DuViktor VeghDavid C ReutensPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 10, p e1002733 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jiaxin Du Viktor Vegh David C Reutens The laminar cortex model: a new continuum cortex model incorporating laminar architecture.
description	Local field potentials (LFPs) are widely used to study the function of local networks in the brain. They are also closely correlated with the blood-oxygen-level-dependent signal, the predominant contrast mechanism in functional magnetic resonance imaging. We developed a new laminar cortex model (LCM) to simulate the amplitude and frequency of LFPs. Our model combines the laminar architecture of the cerebral cortex and multiple continuum models to simulate the collective activity of cortical neurons. The five cortical layers (layer I, II/III, IV, V, and VI) are simulated as separate continuum models between which there are synaptic connections. The LCM was used to simulate the dynamics of the visual cortex under different conditions of visual stimulation. LFPs are reported for two kinds of visual stimulation: general visual stimulation and intermittent light stimulation. The power spectra of LFPs were calculated and compared with existing empirical data. The LCM was able to produce spontaneous LFPs exhibiting frequency-inverse (1/ƒ) power spectrum behaviour. Laminar profiles of current source density showed similarities to experimental data. General stimulation enhanced the oscillation of LFPs corresponding to gamma frequencies. During simulated intermittent light stimulation, the LCM captured the fundamental as well as high order harmonics as previously reported. The power spectrum expected with a reduction in layer IV neurons, often observed with focal cortical dysplasias associated with epilepsy was also simulated.
format	article
author	Jiaxin Du Viktor Vegh David C Reutens
author_facet	Jiaxin Du Viktor Vegh David C Reutens
author_sort	Jiaxin Du
title	The laminar cortex model: a new continuum cortex model incorporating laminar architecture.
title_short	The laminar cortex model: a new continuum cortex model incorporating laminar architecture.
title_full	The laminar cortex model: a new continuum cortex model incorporating laminar architecture.
title_fullStr	The laminar cortex model: a new continuum cortex model incorporating laminar architecture.
title_full_unstemmed	The laminar cortex model: a new continuum cortex model incorporating laminar architecture.
title_sort	laminar cortex model: a new continuum cortex model incorporating laminar architecture.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/cf718ef9e623473595c014b096a95c96
work_keys_str_mv	AT jiaxindu thelaminarcortexmodelanewcontinuumcortexmodelincorporatinglaminararchitecture AT viktorvegh thelaminarcortexmodelanewcontinuumcortexmodelincorporatinglaminararchitecture AT davidcreutens thelaminarcortexmodelanewcontinuumcortexmodelincorporatinglaminararchitecture AT jiaxindu laminarcortexmodelanewcontinuumcortexmodelincorporatinglaminararchitecture AT viktorvegh laminarcortexmodelanewcontinuumcortexmodelincorporatinglaminararchitecture AT davidcreutens laminarcortexmodelanewcontinuumcortexmodelincorporatinglaminararchitecture
_version_	1718424756278001664

The laminar cortex model: a new continuum cortex model incorporating laminar architecture.

Ejemplares similares