Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines

Abstract Epstein-Barr virus (EBV) was identified as the first human virus to be associated with a human malignancy, Burkitt’s lymphoma (BL), a pediatric cancer endemic in sub-Saharan Africa. The exact mechanism of how EBV contributes to the process of lymphomagenesis is not fully understood. Recent...

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Autores principales:	Hector Hernandez-Vargas, Henri Gruffat, Marie Pierre Cros, Audrey Diederichs, Cécilia Sirand, Romina C. Vargas-Ayala, Antonin Jay, Geoffroy Durand, Florence Le Calvez-Kelm, Zdenko Herceg, Evelyne Manet, Christopher P. Wild, Massimo Tommasino, Rosita Accardi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf771775f0f0480bba14d8ec7e78bb0a
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spelling	oai:doaj.org-article:cf771775f0f0480bba14d8ec7e78bb0a2021-12-02T11:53:05ZViral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines10.1038/s41598-017-05713-22045-2322https://doaj.org/article/cf771775f0f0480bba14d8ec7e78bb0a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05713-2https://doaj.org/toc/2045-2322Abstract Epstein-Barr virus (EBV) was identified as the first human virus to be associated with a human malignancy, Burkitt’s lymphoma (BL), a pediatric cancer endemic in sub-Saharan Africa. The exact mechanism of how EBV contributes to the process of lymphomagenesis is not fully understood. Recent studies have highlighted a genetic difference between endemic (EBV+) and sporadic (EBV−) BL, with the endemic variant showing a lower somatic mutation load, which suggests the involvement of an alternative virally-driven process of transformation in the pathogenesis of endemic BL. We tested the hypothesis that a global change in DNA methylation may be induced by infection with EBV, possibly thereby accounting for the lower mutation load observed in endemic BL. Our comparative analysis of the methylation profiles of a panel of BL derived cell lines, naturally infected or not with EBV, revealed that the presence of the virus is associated with a specific pattern of DNA methylation resulting in altered expression of cellular genes with a known or potential role in lymphomagenesis. These included ID3, a gene often found to be mutated in sporadic BL. In summary this study provides evidence that EBV may contribute to the pathogenesis of BL through an epigenetic mechanism.Hector Hernandez-VargasHenri GruffatMarie Pierre CrosAudrey DiederichsCécilia SirandRomina C. Vargas-AyalaAntonin JayGeoffroy DurandFlorence Le Calvez-KelmZdenko HercegEvelyne ManetChristopher P. WildMassimo TommasinoRosita AccardiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hector Hernandez-Vargas Henri Gruffat Marie Pierre Cros Audrey Diederichs Cécilia Sirand Romina C. Vargas-Ayala Antonin Jay Geoffroy Durand Florence Le Calvez-Kelm Zdenko Herceg Evelyne Manet Christopher P. Wild Massimo Tommasino Rosita Accardi Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
description	Abstract Epstein-Barr virus (EBV) was identified as the first human virus to be associated with a human malignancy, Burkitt’s lymphoma (BL), a pediatric cancer endemic in sub-Saharan Africa. The exact mechanism of how EBV contributes to the process of lymphomagenesis is not fully understood. Recent studies have highlighted a genetic difference between endemic (EBV+) and sporadic (EBV−) BL, with the endemic variant showing a lower somatic mutation load, which suggests the involvement of an alternative virally-driven process of transformation in the pathogenesis of endemic BL. We tested the hypothesis that a global change in DNA methylation may be induced by infection with EBV, possibly thereby accounting for the lower mutation load observed in endemic BL. Our comparative analysis of the methylation profiles of a panel of BL derived cell lines, naturally infected or not with EBV, revealed that the presence of the virus is associated with a specific pattern of DNA methylation resulting in altered expression of cellular genes with a known or potential role in lymphomagenesis. These included ID3, a gene often found to be mutated in sporadic BL. In summary this study provides evidence that EBV may contribute to the pathogenesis of BL through an epigenetic mechanism.
format	article
author	Hector Hernandez-Vargas Henri Gruffat Marie Pierre Cros Audrey Diederichs Cécilia Sirand Romina C. Vargas-Ayala Antonin Jay Geoffroy Durand Florence Le Calvez-Kelm Zdenko Herceg Evelyne Manet Christopher P. Wild Massimo Tommasino Rosita Accardi
author_facet	Hector Hernandez-Vargas Henri Gruffat Marie Pierre Cros Audrey Diederichs Cécilia Sirand Romina C. Vargas-Ayala Antonin Jay Geoffroy Durand Florence Le Calvez-Kelm Zdenko Herceg Evelyne Manet Christopher P. Wild Massimo Tommasino Rosita Accardi
author_sort	Hector Hernandez-Vargas
title	Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
title_short	Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
title_full	Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
title_fullStr	Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
title_full_unstemmed	Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines
title_sort	viral driven epigenetic events alter the expression of cancer-related genes in epstein-barr-virus naturally infected burkitt lymphoma cell lines
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cf771775f0f0480bba14d8ec7e78bb0a
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Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines

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